ID   AIM14_CLAL4             Reviewed;         513 AA.
AC   C4Y9R6;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Probable metalloreductase AIM14;
DE            EC=1.16.1.-;
GN   Name=AIM14; ORFNames=CLUG_05137;
OS   Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Metschnikowiaceae; Clavispora.
OX   NCBI_TaxID=306902;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42720;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Probable cell surface metalloreductase. May be involved in
CC       iron or copper homeostasis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ferric reductase (FRE) family. AIM14
CC       subfamily. {ECO:0000305}.
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DR   EMBL; CH408081; EEQ41009.1; -; Genomic_DNA.
DR   RefSeq; XP_002615122.1; XM_002615076.1.
DR   AlphaFoldDB; C4Y9R6; -.
DR   SMR; C4Y9R6; -.
DR   STRING; 306902.C4Y9R6; -.
DR   EnsemblFungi; EEQ41009; EEQ41009; CLUG_05137.
DR   GeneID; 8495554; -.
DR   KEGG; clu:CLUG_05137; -.
DR   VEuPathDB; FungiDB:CLUG_05137; -.
DR   HOGENOM; CLU_036508_0_0_1; -.
DR   InParanoid; C4Y9R6; -.
DR   OMA; LIPLHKW; -.
DR   Proteomes; UP000007703; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.80; -; 1.
DR   InterPro; IPR013112; FAD-bd_8.
DR   InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR   InterPro; IPR013121; Fe_red_NAD-bd_6.
DR   InterPro; IPR039261; FNR_nucleotide-bd.
DR   Pfam; PF08022; FAD_binding_8; 1.
DR   Pfam; PF01794; Ferric_reduct; 1.
DR   Pfam; PF08030; NAD_binding_6; 1.
DR   SUPFAM; SSF52343; SSF52343; 1.
PE   3: Inferred from homology;
KW   Electron transport; FAD; Flavoprotein; Ion transport; Membrane; NADP;
KW   Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..513
FT                   /note="Probable metalloreductase AIM14"
FT                   /id="PRO_0000408743"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          100..211
FT                   /note="Ferric oxidoreductase"
FT   DOMAIN          240..368
FT                   /note="FAD-binding FR-type"
SQ   SEQUENCE   513 AA;  57083 MW;  DB486BC841E4CCF6 CRC64;
     MTTSKIGVRH AGHGHTVNIK YGYIIFGVSV LYALLLASAH FLELRQWRRQ KRPSRSSVWA
     RINNAPFWVH TLLWAAIVVG LAFTNVHDLS QNWTVVVKRL GRLAFCLVPL DLALALRPCL
     LGQSYLELMP LHKWLSRLII LAGVVHGIGF FVKWTIHHQL GKAKRWANLA GIIVALFSVL
     LVIVSSRPVR RRFYSYFYAF HNFTVALFVL LMIWHARPGV SDFVLLSVAL LLFQGASRVY
     NGYSVPGLTI VDADAASLRL LRLQKPNSFP SVWQPGSHIR VGLPLSSWQS WVFPAHLYTL
     CSSPANDTLN LVVKKGRRFE MLTSLEYRVS CPYASLPTPW LSTAENVHIV CGGSGISLGI
     PLYEYFDNKS SVLANLHWCV SNARDTFVLS ELGVNNPVNV YVTSGKIDQS SYDDADNEDA
     GLLGAGDNIE LEPIPAENKS NPFTDDHAVN CAEQRIQMHA GRPNLSEILA SFSETDDNAH
     KLLIVCGPVG LIRDVRAYGD AHGIAVFSEL YNM