ID   FAD11_MYCTU             Reviewed;         571 AA.
AC   P9WQ53; L0T9R9; Q10776;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Putative fatty-acid--CoA ligase fadD11;
DE            EC=6.2.1.-;
DE   AltName: Full=Acyl-CoA synthetase;
GN   Name=fadD11; OrderedLocusNames=Rv1550; ORFNames=MTCY48.15c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP44314.1; -; Genomic_DNA.
DR   PIR; C70762; C70762.
DR   RefSeq; NP_216066.1; NC_000962.3.
DR   RefSeq; WP_003898924.1; NC_000962.3.
DR   AlphaFoldDB; P9WQ53; -.
DR   STRING; 83332.Rv1550; -.
DR   PaxDb; P9WQ53; -.
DR   DNASU; 886380; -.
DR   GeneID; 886380; -.
DR   KEGG; mtu:Rv1550; -.
DR   TubercuList; Rv1550; -.
DR   eggNOG; COG1022; Bacteria.
DR   OMA; RGMRKYD; -.
DR   PhylomeDB; P9WQ53; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0016405; F:CoA-ligase activity; IBA:GO_Central.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.12780; -; 2.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; ANL_N_sf.
DR   Pfam; PF00501; AMP-binding; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Fatty acid metabolism; Ligase; Lipid metabolism; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..571
FT                   /note="Putative fatty-acid--CoA ligase fadD11"
FT                   /id="PRO_0000193133"
FT   TRANSMEM        314..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          67..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   571 AA;  62309 MW;  37043842FBC9CD31 CRC64;
     MARLRGAGAA GRCRPGRFGS SARRHGLADD GEPDRVLPAR RRCSARRRHL VFGVQHPARR
     AADLRVRQRG DQGGHLRATV RRSRSRQRCA HRTHRLRRWR APGTLSLTDL YAAASGDFFD
     FESTWRAVQP EDIVTLIYTS GTTGNPKGVE MTHANLLFEG YAIDEVLGIR FGDRVTSFLP
     SAHIADRMTG LYLQEMFGTQ VTAVADARTI AAALPDVRPT VWGAVPRVWE KLKAGIEFTV
     ARETDEMKRQ ALAWAMSVAG KRANALLAGE SMSDQLVAEW AKADELVLSK LRERLGFGEL
     RWALSGAAPI PKETLAFFAG IGIPIAEIWG MSELSCVATA SHPRDGRLGT VGKLLPGLQG
     KIAEDGEYLV RGPLVMKGYR KEPAKTAEAI DSDGWLHTGD VFDIDSDGYL RVVDRKKELI
     INAAGKNMSP ANIENTILAA CPMVGVMMAI GDGRTYNTAL LVFDADSLGP YAAQRGLDAS
     PAALAADPEV IARIAAGVAE GNAKLSRVEQ IKRFRILPTL WEPGGDEITL TMKLKRRRIA
     AKYSAEIEEL YASELRPQVY EPAAVPSTQP A