ID   AIM14_LACTC             Reviewed;         533 AA.
AC   C5E398;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Probable metalloreductase AIM14;
DE            EC=1.16.1.-;
GN   Name=AIM14; OrderedLocusNames=KLTH0H11550g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Probable cell surface metalloreductase. May be involved in
CC       iron or copper homeostasis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ferric reductase (FRE) family. AIM14
CC       subfamily. {ECO:0000305}.
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DR   EMBL; CU928180; CAR30509.1; -; Genomic_DNA.
DR   RefSeq; XP_002556371.1; XM_002556325.1.
DR   AlphaFoldDB; C5E398; -.
DR   SMR; C5E398; -.
DR   STRING; 559295.C5E398; -.
DR   EnsemblFungi; CAR30509; CAR30509; KLTH0H11550g.
DR   GeneID; 8294705; -.
DR   KEGG; lth:KLTH0H11550g; -.
DR   eggNOG; KOG0039; Eukaryota.
DR   HOGENOM; CLU_036508_0_0_1; -.
DR   InParanoid; C5E398; -.
DR   OMA; LIPLHKW; -.
DR   OrthoDB; 936110at2759; -.
DR   Proteomes; UP000002036; Chromosome H.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.80; -; 1.
DR   InterPro; IPR013112; FAD-bd_8.
DR   InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR   InterPro; IPR013121; Fe_red_NAD-bd_6.
DR   InterPro; IPR039261; FNR_nucleotide-bd.
DR   Pfam; PF08022; FAD_binding_8; 1.
DR   Pfam; PF01794; Ferric_reduct; 1.
DR   Pfam; PF08030; NAD_binding_6; 1.
DR   SUPFAM; SSF52343; SSF52343; 1.
PE   3: Inferred from homology;
KW   Electron transport; FAD; Flavoprotein; Ion transport; Membrane; NADP;
KW   Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..533
FT                   /note="Probable metalloreductase AIM14"
FT                   /id="PRO_0000408746"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          96..213
FT                   /note="Ferric oxidoreductase"
FT   DOMAIN          240..366
FT                   /note="FAD-binding FR-type"
SQ   SEQUENCE   533 AA;  59726 MW;  C74A2244BF1F6ED4 CRC64;
     MAMTLLPRHG KTHLANIPYG YYTATVSLIF IILLIGARKL IPVRQRNRSK WAKWALSSAR
     GGSPLLYLVV LFVALLVPFV HHYSLLGYVG LYLKRLGRLS YVLATLNLFL TLRPNFLLPG
     YVYLDLIPLH KWLSRSLCLL ALVHGVGFLV KWALDSQVSF VAKAFYNIPN LAGLVVGALM
     AFMVLLSVRP VRRFSYRSFY LTHIIGAWVF VFLTAYHARP GVFVPYTLLN AGLFVFYILS
     KTVPARGVEL VSKSTDDVNN CLTRIVLPRK AMPEHFAPGS HLRISPYRRV NPLYYMLPSH
     PYTVASMPED KDVELIVREH ASGFHLLTGL GYTIQNHYES VPRQCLQSAT RIALVCGGSG
     LSYALPIFRH FASEEKADQV KYLRLIWLVR DKYDVNVLGN IRSLASSVAQ FDIFVTRSVP
     PDDTVESGSK LSPAQQQSPI TDDLEFELES FGDQLDQNGA LITPEIPNLP SGLASSFHFG
     RKLDWMTDLA QFVEREDLGS TWLVACGPKG LNDAAKLYAQ QNEINLASET YAL