ID   FAD21_MYCTO             Reviewed;         578 AA.
AC   P9WQ48; L0T5X7; O50441; P63523;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Putative fatty-acid--CoA ligase fadD21;
DE            EC=6.2.1.-;
DE   AltName: Full=Acyl-CoA synthetase;
GN   Name=fadD21; OrderedLocusNames=MT1222;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK45479.1; -; Genomic_DNA.
DR   PIR; A70877; A70877.
DR   RefSeq; WP_003406196.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WQ48; -.
DR   SMR; P9WQ48; -.
DR   EnsemblBacteria; AAK45479; AAK45479; MT1222.
DR   KEGG; mtc:MT1222; -.
DR   PATRIC; fig|83331.31.peg.1321; -.
DR   HOGENOM; CLU_000022_23_7_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR   CDD; cd05931; FAAL; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; -; 1.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR040097; FAAL/FAAC.
DR   Pfam; PF00501; AMP-binding; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism; Ligase; Lipid metabolism.
FT   CHAIN           1..578
FT                   /note="Putative fatty-acid--CoA ligase fadD21"
FT                   /id="PRO_0000426838"
SQ   SEQUENCE   578 AA;  62757 MW;  698FE8FE9E4BFA2F CRC64;
     MSDSSVLSLL RERAGLQPDD AAFTYIDYEQ DWAGITETLT WSEVFRRTRI VAHEVRRHCT
     TGDRAVILAP QGLAYIAAFL GSMQAGAIAV PLSVPQIGSH DERVSAVLAD ASPSVILTTS
     AVAEAVAEHI HRPNTNNVGP IIEIDSLDLT GNSPSFRVKD LPSAAYLQYT SGSTRAPAGV
     MISHRNLQAN FQQLMSNYFG DRNGVAPPDT TIVSWLPFYH DMGLVLGIIA PILGGYRSEL
     TSPLAFLQRP ARWLHSLANG SPSWSAAPNF AFELAVRKTT DADIEGLDLG NVLGITSGAE
     RVHPNTLSRF CNRFAPYNFR EDMIRPSYGL AEATLYVASR NSGDKPEVVY FEPDKLSTGS
     ANRCEPKTGT PLLSYGMPTS PTVRIVDPDT CIECPAGTIG EIWVKGDNVA EGYWNKPDET
     RHTFGAMLVH PSAGTPDGSW LRTGDLGFLS EDEMFIVGRM KDMLIVYGRN HYPEDIESTV
     QEITGGRVAA ISVPVDHTEK LVTVIELKLL GDSAGEAMDE LDVIKNNVTA AISRSHGLNV
     ADLVLVPPGS IPTTTSGKIR RAACVEQYRL QQFTRLDG