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AIM14_PICGU
ID   AIM14_PICGU             Reviewed;         482 AA.
AC   A5DE11;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Probable metalloreductase AIM14;
DE            EC=1.16.1.-;
GN   Name=AIM14; ORFNames=PGUG_01512;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Probable cell surface metalloreductase. May be involved in
CC       iron or copper homeostasis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ferric reductase (FRE) family. AIM14
CC       subfamily. {ECO:0000305}.
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DR   EMBL; CH408156; EDK37414.2; -; Genomic_DNA.
DR   RefSeq; XP_001485841.1; XM_001485791.1.
DR   AlphaFoldDB; A5DE11; -.
DR   SMR; A5DE11; -.
DR   STRING; 4929.XP_001485841.1; -.
DR   EnsemblFungi; EDK37414; EDK37414; PGUG_01512.
DR   GeneID; 5127468; -.
DR   KEGG; pgu:PGUG_01512; -.
DR   VEuPathDB; FungiDB:PGUG_01512; -.
DR   eggNOG; KOG0039; Eukaryota.
DR   HOGENOM; CLU_036508_0_0_1; -.
DR   InParanoid; A5DE11; -.
DR   OMA; LIPLHKW; -.
DR   OrthoDB; 936110at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.80; -; 1.
DR   InterPro; IPR013112; FAD-bd_8.
DR   InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR   InterPro; IPR013121; Fe_red_NAD-bd_6.
DR   InterPro; IPR039261; FNR_nucleotide-bd.
DR   Pfam; PF08022; FAD_binding_8; 1.
DR   Pfam; PF01794; Ferric_reduct; 1.
DR   Pfam; PF08030; NAD_binding_6; 1.
DR   SUPFAM; SSF52343; SSF52343; 1.
PE   3: Inferred from homology;
KW   Electron transport; FAD; Flavoprotein; Ion transport; Membrane; NADP;
KW   Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..482
FT                   /note="Probable metalloreductase AIM14"
FT                   /id="PRO_0000408747"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          86..198
FT                   /note="Ferric oxidoreductase"
FT   DOMAIN          225..348
FT                   /note="FAD-binding FR-type"
SQ   SEQUENCE   482 AA;  54837 MW;  D4A8B874DBD4D2FF CRC64;
     MHNHPRHEGH LHTVNVKYGY VVFLLSIVHI VVVATVPRLR KVGSSSTRRS LPWLPQIVIW
     AILLAILGVW NIHEWSEHYN VSIKRFGRMA YCLLPFDILL AYKYWPLENY LQNLNLHKWM
     SRIIVVCSMI HGIGYFVKWF VEGTFFHHLF KIDNLLGVVV FAAAVVLLVV SVALFRRQSY
     RLFYVSHNIT IGMFVVLILF HARPPVTLFV AICGLLLAIL FFIKFQTYSA TPVSLKEVPN
     SSLVLVSFPW PDHIATSFKP GSHVRINHSN RSWKSWVFAS HPFTSATLPG TSETLDLVVK
     KGTFIFAKDT QYNLSSPYTS LSFDDNSISR FDQSVIICGG SGISLAIPVF KYLITKLDVT
     MIWCTRSKAD LFVLRHYSLL DKVQVYITGN DSLSVEDESE GHGLMHETIE LENLEESSKN
     SEATKQPEIL RGRPDLNNVC ASLETTPNSS CVISCGPRSL VKDCENWCRN HKIESVTEIY
     EM
 
 
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