ID   AIM14_ZYGRC             Reviewed;         526 AA.
AC   C5E4F2;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Probable metalloreductase AIM14;
DE            EC=1.16.1.-;
GN   Name=AIM14; OrderedLocusNames=ZYRO0E05456g;
OS   Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS   / NRRL Y-229) (Candida mogii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX   NCBI_TaxID=559307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC   Y-229;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Probable cell surface metalloreductase. May be involved in
CC       iron or copper homeostasis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ferric reductase (FRE) family. AIM14
CC       subfamily. {ECO:0000305}.
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DR   EMBL; CU928181; CAR30913.1; -; Genomic_DNA.
DR   RefSeq; XP_002499168.1; XM_002499123.1.
DR   AlphaFoldDB; C5E4F2; -.
DR   SMR; C5E4F2; -.
DR   STRING; 559307.C5E4F2; -.
DR   EnsemblFungi; CAR30913; CAR30913; ZYRO0E05456g.
DR   GeneID; 8204720; -.
DR   KEGG; zro:ZYRO0E05456g; -.
DR   HOGENOM; CLU_036508_0_0_1; -.
DR   InParanoid; C5E4F2; -.
DR   Proteomes; UP000008536; Chromosome E.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.80; -; 1.
DR   InterPro; IPR013112; FAD-bd_8.
DR   InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR   InterPro; IPR013121; Fe_red_NAD-bd_6.
DR   InterPro; IPR039261; FNR_nucleotide-bd.
DR   Pfam; PF08022; FAD_binding_8; 1.
DR   Pfam; PF01794; Ferric_reduct; 1.
DR   Pfam; PF08030; NAD_binding_6; 1.
DR   SUPFAM; SSF52343; SSF52343; 1.
PE   3: Inferred from homology;
KW   Electron transport; FAD; Flavoprotein; Ion transport; Membrane; NADP;
KW   Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..526
FT                   /note="Probable metalloreductase AIM14"
FT                   /id="PRO_0000408755"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          97..214
FT                   /note="Ferric oxidoreductase"
FT   DOMAIN          238..370
FT                   /note="FAD-binding FR-type"
SQ   SEQUENCE   526 AA;  59745 MW;  ED81EDE4D7FFEEAA CRC64;
     MSSELVKRHG HTHYANIPYG YYVLIVSFFY LVFLGVLRII LKPRAAGFNS SKRSRLAQKL
     YLVNPVVHLP ILLVAVLLPF YRHYSISEHA TVYIKRLGRL SYALLPLNLL LNLRPNWLLR
     NNYTYTDLIP LHKWLSRCII IIAVVHGILF LINWALGESG TLAKKIANPY NLAGVLLFAP
     LISMIFFSIG PMRRFSYNAF YVIHNLTGIS FIFVVAFHAR PSVTIPYLLI NIAILLWQGF
     AKFYYAKRTD ILSKNTDYQN TNLVNVQLPR MALPDQFEPA CHIRISPYSR LHPLYWLYPS
     HPFTVASLPS DTVVDLIISE SHHPKSFKLE LGAPYSVINN FDPAVPRSCL EQAKRVAIVC
     GGSGISFGLP LYRYFKEIHP VEYIQFIWLV KDAYQLKILD KLDTIGLLDG SNDCHAFITR
     SVDDPNSNQE TAPDLEFELE SMTQDVVDEN GAFVSERDGS PTSKFKFASI NLGRRIDWAT
     DLSQFVEPAL VDNTWLLTCG PSDLIESGRQ YAADNSINFA SEIYAL