ID   3MGH_EHRCR              Reviewed;         180 AA.
AC   Q2GHI5;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Putative 3-methyladenine DNA glycosylase {ECO:0000255|HAMAP-Rule:MF_00527};
DE            EC=3.2.2.- {ECO:0000255|HAMAP-Rule:MF_00527};
GN   OrderedLocusNames=ECH_0277;
OS   Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Ehrlichia.
OX   NCBI_TaxID=205920;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC CRL-10679 / Arkansas;
RX   PubMed=16482227; DOI=10.1371/journal.pgen.0020021;
RA   Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V.,
RA   Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M.,
RA   Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N., Nelson W.C.,
RA   Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J.P., Daugherty S.C.,
RA   Davidsen T., Durkin A.S., Gwinn M.L., Haft D.H., Selengut J.D.,
RA   Sullivan S.A., Zafar N., Zhou L., Benahmed F., Forberger H., Halpin R.,
RA   Mulligan S., Robinson J., White O., Rikihisa Y., Tettelin H.;
RT   "Comparative genomics of emerging human ehrlichiosis agents.";
RL   PLoS Genet. 2:208-222(2006).
CC   -!- SIMILARITY: Belongs to the DNA glycosylase MPG family.
CC       {ECO:0000255|HAMAP-Rule:MF_00527}.
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DR   EMBL; CP000236; ABD44538.1; -; Genomic_DNA.
DR   RefSeq; WP_011452502.1; NC_007799.1.
DR   AlphaFoldDB; Q2GHI5; -.
DR   SMR; Q2GHI5; -.
DR   STRING; 205920.ECH_0277; -.
DR   EnsemblBacteria; ABD44538; ABD44538; ECH_0277.
DR   KEGG; ech:ECH_0277; -.
DR   eggNOG; COG2094; Bacteria.
DR   HOGENOM; CLU_060471_4_1_5; -.
DR   OMA; LPWRWYL; -.
DR   OrthoDB; 1385409at2; -.
DR   Proteomes; UP000008320; Chromosome.
DR   GO; GO:0003905; F:alkylbase DNA N-glycosylase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR   CDD; cd00540; AAG; 1.
DR   Gene3D; 3.10.300.10; -; 1.
DR   HAMAP; MF_00527; 3MGH; 1.
DR   InterPro; IPR011034; Formyl_transferase-like_C_sf.
DR   InterPro; IPR003180; MPG.
DR   InterPro; IPR036995; MPG_sf.
DR   PANTHER; PTHR10429; PTHR10429; 1.
DR   Pfam; PF02245; Pur_DNA_glyco; 1.
DR   SUPFAM; SSF50486; SSF50486; 1.
DR   TIGRFAMs; TIGR00567; 3mg; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Hydrolase; Reference proteome.
FT   CHAIN           1..180
FT                   /note="Putative 3-methyladenine DNA glycosylase"
FT                   /id="PRO_0000265017"
SQ   SEQUENCE   180 AA;  20405 MW;  71222BBE8A164586 CRC64;
     MPHYILKKSF YEQSSLTVAG KLLGKKLLFN QHQGIITETE AYIGQDDPAA HSARGYTKRT
     SVMFGSPGFS YVYFIYGMYY CLNVVTEQEG FPAAVLIRGI VLLSENKPNT IINGPGKLCK
     ILQITKEHNN TDITQKYNFC ICNTDINIDN YICTPRIGIS KGKEKFWRFV IPDLTFLLNV