AIM18_YEAST
ID AIM18_YEAST Reviewed; 321 AA.
AC P38884; D3DLE6;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Altered inheritance of mitochondria protein 18, mitochondrial;
DE AltName: Full=Found in mitochondrial proteome protein 22;
DE Flags: Precursor;
GN Name=AIM18; Synonyms=FMP22; OrderedLocusNames=YHR198C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091229; DOI=10.1126/science.8091229;
RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA Waterston R., Wilson R., Vaudin M.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT VIII.";
RL Science 265:2077-2082(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP DISRUPTION PHENOTYPE.
RX PubMed=19300474; DOI=10.1371/journal.pgen.1000407;
RA Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J.,
RA Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M.,
RA Troyanskaya O.G., Caudy A.A.;
RT "Computationally driven, quantitative experiments discover genes required
RT for mitochondrial biogenesis.";
RL PLoS Genet. 5:E1000407-E1000407(2009).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14562095}.
CC -!- DISRUPTION PHENOTYPE: Increases frequency of mitochondrial genome loss.
CC {ECO:0000269|PubMed:19300474}.
CC -!- MISCELLANEOUS: Present with 1350 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the AIM18/AIM46 family. {ECO:0000305}.
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DR EMBL; U00030; AAB68373.1; -; Genomic_DNA.
DR EMBL; AY558106; AAS56432.1; -; Genomic_DNA.
DR EMBL; BK006934; DAA06890.1; -; Genomic_DNA.
DR PIR; S46690; S46690.
DR RefSeq; NP_012068.1; NM_001179329.1.
DR AlphaFoldDB; P38884; -.
DR SMR; P38884; -.
DR BioGRID; 36632; 224.
DR DIP; DIP-1697N; -.
DR IntAct; P38884; 2.
DR MINT; P38884; -.
DR STRING; 4932.YHR198C; -.
DR MaxQB; P38884; -.
DR PaxDb; P38884; -.
DR PRIDE; P38884; -.
DR EnsemblFungi; YHR198C_mRNA; YHR198C; YHR198C.
DR GeneID; 856605; -.
DR KEGG; sce:YHR198C; -.
DR SGD; S000001241; AIM18.
DR VEuPathDB; FungiDB:YHR198C; -.
DR eggNOG; ENOG502RGD3; Eukaryota.
DR GeneTree; ENSGT00940000176696; -.
DR HOGENOM; CLU_038840_0_0_1; -.
DR InParanoid; P38884; -.
DR OMA; LGIYVAN; -.
DR BioCyc; YEAST:G3O-31226-MON; -.
DR PRO; PR:P38884; -.
DR Proteomes; UP000002311; Chromosome VIII.
DR RNAct; P38884; protein.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0016872; F:intramolecular lyase activity; IEA:InterPro.
DR Gene3D; 3.50.70.10; -; 1.
DR InterPro; IPR016087; Chalcone_isomerase.
DR InterPro; IPR016088; Chalcone_isomerase_3-sand.
DR InterPro; IPR036298; Chalcone_isomerase_sf.
DR Pfam; PF16035; Chalcone_2; 1.
DR SUPFAM; SSF54626; SSF54626; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..72
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 73..321
FT /note="Altered inheritance of mitochondria protein 18,
FT mitochondrial"
FT /id="PRO_0000202939"
SQ SEQUENCE 321 AA; 36502 MW; A6C07E03AE1EEC80 CRC64;
MDRGRCANML KSLQRTLAKC QKSPSTNHWQ CFKRNFTSIR ATKYPGRSNS TFHYWPWFAA
STLLATSLYY RDRPVQNDDK TDAFPSHTES IQVDSSVSDF PLTITALNFP VSTTFKLLGY
GQRHVTFLRF KVYALGLYLA ENDENLVSDT LNETYLHKYF LDVDDSKTPK ENLARLLKRD
DSKSVMMIDD LLDSGMRMLA KITPVRNTDF KHLKEGLVKT ISKHPDVANN KDTLAKGLSE
LNDAFSRKGS VRKNDDLIIE LLANGALQFS YHDSKNNEFE VMGVVNNQLV GKFLFSQYLC
GEKSPSPQAK KTAIDKLITL L
