AIM19_YEAST
ID AIM19_YEAST Reviewed; 157 AA.
AC P40502; D6VVK0;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Altered inheritance of mitochondria protein 19, mitochondrial;
GN Name=AIM19; OrderedLocusNames=YIL087C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169870;
RA Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
RA Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E.,
RA Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C.,
RA Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V.,
RA Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
RL Nature 387:84-87(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP DISRUPTION PHENOTYPE.
RX PubMed=19300474; DOI=10.1371/journal.pgen.1000407;
RA Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J.,
RA Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M.,
RA Troyanskaya O.G., Caudy A.A.;
RT "Computationally driven, quantitative experiments discover genes required
RT for mitochondrial biogenesis.";
RL PLoS Genet. 5:E1000407-E1000407(2009).
RN [6]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 76625 / YPH499;
RX PubMed=14576278; DOI=10.1073/pnas.2135385100;
RA Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E.,
RA Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P.,
RA Pfanner N., Meisinger C.;
RT "The proteome of Saccharomyces cerevisiae mitochondria.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003).
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}; Multi-pass
CC membrane protein {ECO:0000269|PubMed:14562095,
CC ECO:0000269|PubMed:14576278}.
CC -!- DISRUPTION PHENOTYPE: Increases frequency of mitochondrial genome loss.
CC {ECO:0000269|PubMed:19300474}.
CC -!- SIMILARITY: Belongs to the AIM19 family. {ECO:0000305}.
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DR EMBL; Z46728; CAA86707.1; -; Genomic_DNA.
DR EMBL; AY558539; AAS56865.1; -; Genomic_DNA.
DR EMBL; BK006942; DAA08466.1; -; Genomic_DNA.
DR PIR; S49793; S49793.
DR RefSeq; NP_012179.3; NM_001179435.3.
DR AlphaFoldDB; P40502; -.
DR BioGRID; 34906; 51.
DR STRING; 4932.YIL087C; -.
DR iPTMnet; P40502; -.
DR MaxQB; P40502; -.
DR PaxDb; P40502; -.
DR PRIDE; P40502; -.
DR EnsemblFungi; YIL087C_mRNA; YIL087C; YIL087C.
DR GeneID; 854722; -.
DR KEGG; sce:YIL087C; -.
DR SGD; S000001349; AIM19.
DR VEuPathDB; FungiDB:YIL087C; -.
DR eggNOG; ENOG502S412; Eukaryota.
DR HOGENOM; CLU_130042_0_0_1; -.
DR InParanoid; P40502; -.
DR OMA; RYGRVWP; -.
DR BioCyc; YEAST:G3O-31347-MON; -.
DR PRO; PR:P40502; -.
DR Proteomes; UP000002311; Chromosome IX.
DR RNAct; P40502; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IPI:SGD.
DR InterPro; IPR019419; AIM19.
DR PANTHER; PTHR28177; PTHR28177; 1.
DR Pfam; PF10315; Aim19; 1.
PE 1: Evidence at protein level;
KW Acetylation; Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22814378"
FT CHAIN 2..157
FT /note="Altered inheritance of mitochondria protein 19,
FT mitochondrial"
FT /id="PRO_0000202977"
FT TRANSMEM 31..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0007744|PubMed:22814378"
SQ SEQUENCE 157 AA; 16924 MW; 32C547FA27327AFB CRC64;
MSAKPATDDA KDELLSPFRR LYALTRTPYP ALANAALLAS TPVLSPSFKV PPTQSPALSI
PMSRVFSKSS TARIGITTKT ALFFSTMQAI GAYMIYDNDL ENGAGFIATW SALYLIVGGK
KSFSALRYGR TWPLVLSSVS LANAVLYGQR FLATGFQ
