ID   FADD_DROPS              Reviewed;         241 AA.
AC   Q297U0;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Fas-associated death domain protein;
DE   AltName: Full=Death domain-containing adapter protein BG4;
GN   Name=Fadd; Synonyms=BG4; ORFNames=GA11540;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Component of the IMD signaling pathway and is required for
CC       the host defense against Gram-negative bacteria. Interacts with Dredd,
CC       promotes cleavage of Dredd and is necessary and sufficient for
CC       enhancing Dredd-induced apoptosis (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: N-terminus interacts with Dredd. Interacts with imd (By
CC       similarity). {ECO:0000250|UniProtKB:Q9V3B4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9V3B4}.
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DR   EMBL; CM000070; EAL28115.2; -; Genomic_DNA.
DR   RefSeq; XP_001358972.2; XM_001358935.3.
DR   AlphaFoldDB; Q297U0; -.
DR   SMR; Q297U0; -.
DR   STRING; 7237.FBpp0281876; -.
DR   EnsemblMetazoa; FBtr0283438; FBpp0281876; FBgn0071591.
DR   GeneID; 4801958; -.
DR   KEGG; dpo:Dpse_GA11540; -.
DR   eggNOG; ENOG502SE91; Eukaryota.
DR   HOGENOM; CLU_093594_0_0_1; -.
DR   InParanoid; Q297U0; -.
DR   OMA; LIEEDDC; -.
DR   Proteomes; UP000001819; Chromosome 2.
DR   Bgee; FBgn0071591; Expressed in female reproductive system and 2 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0050700; F:CARD domain binding; IEA:EnsemblMetazoa.
DR   GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:EnsemblMetazoa.
DR   GO; GO:0006915; P:apoptotic process; ISS:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; ISS:UniProtKB.
DR   GO; GO:0006955; P:immune response; IEA:EnsemblMetazoa.
DR   GO; GO:0061057; P:peptidoglycan recognition protein signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0002230; P:positive regulation of defense response to virus by host; IEA:EnsemblMetazoa.
DR   GO; GO:0007291; P:sperm individualization; IEA:EnsemblMetazoa.
DR   Gene3D; 1.10.533.10; -; 2.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   Pfam; PF00531; Death; 1.
DR   SUPFAM; SSF47986; SSF47986; 2.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Cytoplasm; Reference proteome.
FT   CHAIN           1..241
FT                   /note="Fas-associated death domain protein"
FT                   /id="PRO_0000271423"
FT   DOMAIN          151..237
FT                   /note="Death"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00064"
FT   REGION          1..101
FT                   /note="Death-inducing"
SQ   SEQUENCE   241 AA;  27746 MW;  4439AC9898A7D03D CRC64;
     MPGNHWYDIL KKIACEGSSD IDELKGIFEK ELSKRKFDSI RNIEDLIDVL ERADMLSLHN
     VEPLRKMSSH KPKLIEALDR YGTPVSAPRE PVNIYQEERL AEELRQHLRI SQAFQILSAP
     GVAPPAFIPA AAPTPPPPQQ NYITPAAFTD RKRTAVFNKI SEELGRFWRI FGRKAGIGEG
     TMDDIEERYP RDLKSRILHL LKLIEEDDCH DPRQLLMRLC RALTECGRND IKRKVEQIMS
     H