ID   AIM20_YEAST             Reviewed;         204 AA.
AC   P40451; D6VVC8;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Altered inheritance of mitochondria protein 20;
GN   Name=AIM20; OrderedLocusNames=YIL158W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169870;
RA   Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
RA   Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E.,
RA   Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C.,
RA   Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V.,
RA   Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
RL   Nature 387:84-87(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [4]
RP   FUNCTION.
RX   PubMed=18617996; DOI=10.1371/journal.pgen.1000120;
RA   Niu W., Li Z., Zhan W., Iyer V.R., Marcotte E.M.;
RT   "Mechanisms of cell cycle control revealed by a systematic and quantitative
RT   overexpression screen in S. cerevisiae.";
RL   PLoS Genet. 4:E1000120-E1000120(2008).
RN   [5]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=19300474; DOI=10.1371/journal.pgen.1000407;
RA   Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J.,
RA   Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M.,
RA   Troyanskaya O.G., Caudy A.A.;
RT   "Computationally driven, quantitative experiments discover genes required
RT   for mitochondrial biogenesis.";
RL   PLoS Genet. 5:E1000407-E1000407(2009).
RN   [6]
RP   FUNCTION.
RX   PubMed=20472512; DOI=10.1016/j.dnarep.2010.04.007;
RA   Murakami-Sekimata A., Huang D., Piening B.D., Bangur C., Paulovich A.G.;
RT   "The Saccharomyces cerevisiae RAD9, RAD17 and RAD24 genes are required for
RT   suppression of mutagenic post-replicative repair during chronic DNA
RT   damage.";
RL   DNA Repair 9:824-834(2010).
CC   -!- FUNCTION: Involved in cell cycle progression and surviving DNA damage.
CC       {ECO:0000269|PubMed:18617996, ECO:0000269|PubMed:20472512}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000269|PubMed:14562095};
CC       Single-pass membrane protein {ECO:0000269|PubMed:14562095}.
CC   -!- DISRUPTION PHENOTYPE: Increases frequency of mitochondrial genome loss.
CC       {ECO:0000269|PubMed:19300474}.
CC   -!- SIMILARITY: Belongs to the SKG1 family. {ECO:0000305}.
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DR   EMBL; Z38059; CAA86120.1; -; Genomic_DNA.
DR   EMBL; BK006942; DAA08394.1; -; Genomic_DNA.
DR   PIR; S48376; S48376.
DR   RefSeq; NP_012108.3; NM_001179506.3.
DR   AlphaFoldDB; P40451; -.
DR   BioGRID; 34834; 32.
DR   DIP; DIP-5665N; -.
DR   STRING; 4932.YIL158W; -.
DR   iPTMnet; P40451; -.
DR   MaxQB; P40451; -.
DR   PaxDb; P40451; -.
DR   PRIDE; P40451; -.
DR   EnsemblFungi; YIL158W_mRNA; YIL158W; YIL158W.
DR   GeneID; 854648; -.
DR   KEGG; sce:YIL158W; -.
DR   SGD; S000001420; AIM20.
DR   VEuPathDB; FungiDB:YIL158W; -.
DR   GeneTree; ENSGT00940000176519; -.
DR   HOGENOM; CLU_116407_0_0_1; -.
DR   InParanoid; P40451; -.
DR   OMA; TEMRDID; -.
DR   BioCyc; YEAST:G3O-31406-MON; -.
DR   PRO; PR:P40451; -.
DR   Proteomes; UP000002311; Chromosome IX.
DR   RNAct; P40451; protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; HDA:SGD.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cell cycle; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Vacuole.
FT   CHAIN           1..204
FT                   /note="Altered inheritance of mitochondria protein 20"
FT                   /id="PRO_0000202953"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   204 AA;  22840 MW;  7B86FA9F125F19BF CRC64;
     MGNVSVAVGT AVGIPIAVGV IIALIFWCKL QRRYKKEEIR DADLEKMVME EVAVSVYDGF
     KAEINSSSEA STINEKEANQ DLKPCQEKTA KAGYTPAYRR QLNASMGTLR PKKQSTAYTN
     VPVIFSGEKV NYGMVRDPSY SFMYPLTLSR KETSSLRSAS TSNLSSSTEN TALHEEIKLD
     DPYENDFTNY TVNKREFIDS LRPH