ID   AIM21_KLULA             Reviewed;         603 AA.
AC   Q6CQX5;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Altered inheritance of mitochondria protein 21;
GN   Name=AIM21; OrderedLocusNames=KLLA0D13486g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in mitochondrial migration along actin filaments.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, actin patch
CC       {ECO:0000250}. Note=Cortical actin patches. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AIM21 family. {ECO:0000305}.
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DR   EMBL; CR382124; CAH00760.1; -; Genomic_DNA.
DR   RefSeq; XP_453664.1; XM_453664.1.
DR   AlphaFoldDB; Q6CQX5; -.
DR   STRING; 28985.XP_453664.1; -.
DR   EnsemblFungi; CAH00760; CAH00760; KLLA0_D13486g.
DR   GeneID; 2893000; -.
DR   KEGG; kla:KLLA0_D13486g; -.
DR   eggNOG; ENOG502S25J; Eukaryota.
DR   HOGENOM; CLU_452741_0_0_1; -.
DR   InParanoid; Q6CQX5; -.
DR   OMA; FQQMFNQ; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021582; Aim21.
DR   Pfam; PF11489; Aim21; 4.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..603
FT                   /note="Altered inheritance of mitochondria protein 21"
FT                   /id="PRO_0000399521"
FT   REGION          1..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          163..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          407..457
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          478..603
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..41
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..86
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..192
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        217..239
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        250..266
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        268..284
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        308..330
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        346..362
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        418..439
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        525..548
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        562..578
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   603 AA;  65465 MW;  FC19C1AF32C7101E CRC64;
     MEQVIPKVPE RPRRRITRSE EPEQLRSESE FEREKSGSKD SELDLPPVPK TRPNRKPLAS
     SSAHASSDDV SVKPEPQIQA QLQPEAVIET EPTVEHPIVD ELEAKLPVEQ PVLDEVELDE
     PVTQEVEPSG ELLPEESTIK ESLEEQIIDD FADEPVEEEC KEVASPELIG DEAIQDEELE
     KPVKEEPIIQ TDDKTLAEAI VPSVCEESEA DIAEEPKETP EDASEAVVEA AREESSEVSP
     EASPEVPPEK TQVSVDQLSS TANLTEGAKE APKEEQKETS EATSEETPED SSVNAKPLFK
     EVTPGNVSSK EAIPSNTSPK EGSPATQKKK QGKSPPVPKK PSSKIAAFQQ MFQNQQLQPE
     HTPSPKEPAA PKTGGFSGNR AQFAQNLNGM IALPGMAQLT PALAKRLGVS TSSDDAETGA
     EVETKNTKDE AELPKVPARS KKTRGPHKRL PKTVASIEKV ETKSTSNISV VKAWTISFKP
     DLPERADDQP MEAELTAGEA IAPSEPAGLE DVEAEDLNEA SPEEPLQIIS ESGNSDESEI
     QHTSDPSIAQ NVEHEEEVHE EAEAAPEAEP EAEEIALDTE ESNPTAFIAE TYDEDTEVET
     PTA