ID   3MGH_EHRRW              Reviewed;         188 AA.
AC   Q5HAG4; Q5FDK1;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Putative 3-methyladenine DNA glycosylase {ECO:0000255|HAMAP-Rule:MF_00527};
DE            EC=3.2.2.- {ECO:0000255|HAMAP-Rule:MF_00527};
GN   OrderedLocusNames=Erum7170, ERWE_CDS_07540;
OS   Ehrlichia ruminantium (strain Welgevonden).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Ehrlichia.
OX   NCBI_TaxID=254945;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Welgevonden;
RX   PubMed=15637156; DOI=10.1073/pnas.0406633102;
RA   Collins N.E., Liebenberg J., de Villiers E.P., Brayton K.A., Louw E.,
RA   Pretorius A., Faber F.E., van Heerden H., Josemans A., van Kleef M.,
RA   Steyn H.C., van Strijp M.F., Zweygarth E., Jongejan F., Maillard J.C.,
RA   Berthier D., Botha M., Joubert F., Corton C.H., Thomson N.R., Allsopp M.T.,
RA   Allsopp B.A.;
RT   "The genome of the heartwater agent Ehrlichia ruminantium contains multiple
RT   tandem repeats of actively variable copy number.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:838-843(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Welgevonden;
RX   PubMed=16547041; DOI=10.1128/jb.188.7.2533-2542.2006;
RA   Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y.,
RA   Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.;
RT   "Comparative genomic analysis of three strains of Ehrlichia ruminantium
RT   reveals an active process of genome size plasticity.";
RL   J. Bacteriol. 188:2533-2542(2006).
CC   -!- SIMILARITY: Belongs to the DNA glycosylase MPG family.
CC       {ECO:0000255|HAMAP-Rule:MF_00527}.
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DR   EMBL; CR767821; CAH58449.1; -; Genomic_DNA.
DR   EMBL; CR925678; CAI27248.1; -; Genomic_DNA.
DR   RefSeq; WP_011155396.1; NC_006832.1.
DR   AlphaFoldDB; Q5HAG4; -.
DR   SMR; Q5HAG4; -.
DR   EnsemblBacteria; CAI27248; CAI27248; ERWE_CDS_07540.
DR   GeneID; 56785483; -.
DR   KEGG; eru:Erum7170; -.
DR   KEGG; erw:ERWE_CDS_07540; -.
DR   eggNOG; COG2094; Bacteria.
DR   HOGENOM; CLU_060471_4_1_5; -.
DR   OMA; VEAYHHT; -.
DR   BioCyc; ERUM254945:ERUM_RS03875-MON; -.
DR   Proteomes; UP000001021; Chromosome.
DR   GO; GO:0003905; F:alkylbase DNA N-glycosylase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR   CDD; cd00540; AAG; 1.
DR   Gene3D; 3.10.300.10; -; 1.
DR   HAMAP; MF_00527; 3MGH; 1.
DR   InterPro; IPR011034; Formyl_transferase-like_C_sf.
DR   InterPro; IPR003180; MPG.
DR   InterPro; IPR036995; MPG_sf.
DR   PANTHER; PTHR10429; PTHR10429; 1.
DR   Pfam; PF02245; Pur_DNA_glyco; 1.
DR   SUPFAM; SSF50486; SSF50486; 1.
DR   TIGRFAMs; TIGR00567; 3mg; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Hydrolase.
FT   CHAIN           1..188
FT                   /note="Putative 3-methyladenine DNA glycosylase"
FT                   /id="PRO_0000265019"
SQ   SEQUENCE   188 AA;  21233 MW;  95A3077020AD27FE CRC64;
     MYNILKKSFY KQKSLDVASS LLGKMLLFNQ HKGIITETEA YIGQDDQAAH SFHGYTKRTA
     VMFGNPGFSY VYLIYGMYHC LNVVTEPEGF PAAILIRSII LLSKNTPHTK VNGPGKICKI
     LDITKEHNNI DMTANHSFCI CDTNLNIDDY ICTPRIGISK ATDKFWRFVI PDVTSLQYID
     TKLVPTLT