ID   FADL_ECO57              Reviewed;         446 AA.
AC   Q8XCN6;
DT   20-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 2.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Long-chain fatty acid transport protein;
DE   AltName: Full=Outer membrane FadL protein;
DE   AltName: Full=Outer membrane flp protein;
DE   Flags: Precursor;
GN   Name=fadL; OrderedLocusNames=Z3608, ECs3227;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Involved in translocation of long-chain fatty acids across
CC       the outer membrane. FadL may form a specific channel (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OmpP1/FadL family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG57472.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB36650.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE005174; AAG57472.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000007; BAB36650.1; ALT_INIT; Genomic_DNA.
DR   PIR; C91032; C91032.
DR   PIR; D85876; D85876.
DR   RefSeq; NP_311254.2; NC_002695.1.
DR   RefSeq; WP_001301981.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8XCN6; -.
DR   SMR; Q8XCN6; -.
DR   STRING; 155864.EDL933_3512; -.
DR   EnsemblBacteria; AAG57472; AAG57472; Z3608.
DR   EnsemblBacteria; BAB36650; BAB36650; ECs_3227.
DR   GeneID; 915676; -.
DR   KEGG; ece:Z3608; -.
DR   KEGG; ecs:ECs_3227; -.
DR   PATRIC; fig|386585.9.peg.3369; -.
DR   eggNOG; COG2067; Bacteria.
DR   HOGENOM; CLU_035981_0_0_6; -.
DR   OMA; NRYGFTY; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005017; OMPP1/FadL/TodX.
DR   PANTHER; PTHR35093; PTHR35093; 1.
DR   Pfam; PF03349; Toluene_X; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Lipid transport; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..446
FT                   /note="Long-chain fatty acid transport protein"
FT                   /id="PRO_0000025204"
SQ   SEQUENCE   446 AA;  48539 MW;  09082DDB58D25693 CRC64;
     MSQKTLFTKS ALAVAVALIS TQAWSAGFQL NEFSSSGLGR AYSGEGAIAD DAGNVSRNPA
     LITMFDRPTF SAGAVYIDPD VNISGTSPSG RSLKADNIAP TAWVPNMHFV APINDQFGWG
     ASITSNYGLA TEFNDTYAGG SVGGTTDLET MNLNLSGAYR LNNAWSFGLG FNAVYARAKI
     ERFAGDLGQL VAGQIMQSPA GKTPQGQALA ATANGIDSNT KIAHLNGNQW GFGWNAGILY
     ELDKNNRYAL TYRSEVKIDF KGNYSSDLNR VFNNYGLPIP TATGGATQSG YLTLNLPEMW
     EVSGYNRVDP QWAIHYSLAY TSWSQFQQLK ATSTSGDTLF QKHEGFKDAY RIALGTTYYY
     DDNWTFRTGI AFDDSPVPAQ NRSISIPDQD RFWLSAGTTY AFNKDASVDV GVSYMHGQSV
     KINEGPYQFE SEGKAWLFGT NFNYAF