ID   FADL_ECOL6              Reviewed;         446 AA.
AC   Q8CVU7;
DT   20-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 2.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Long-chain fatty acid transport protein;
DE   AltName: Full=Outer membrane FadL protein;
DE   AltName: Full=Outer membrane flp protein;
DE   Flags: Precursor;
GN   Name=fadL; OrderedLocusNames=c2889;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Involved in translocation of long-chain fatty acids across
CC       the outer membrane. FadL may form a specific channel (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OmpP1/FadL family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN81339.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN81339.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_001350318.1; NC_004431.1.
DR   AlphaFoldDB; Q8CVU7; -.
DR   SMR; Q8CVU7; -.
DR   STRING; 199310.c2889; -.
DR   EnsemblBacteria; AAN81339; AAN81339; c2889.
DR   KEGG; ecc:c2889; -.
DR   eggNOG; COG2067; Bacteria.
DR   HOGENOM; CLU_035981_0_0_6; -.
DR   OMA; NRYGFTY; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005017; OMPP1/FadL/TodX.
DR   PANTHER; PTHR35093; PTHR35093; 1.
DR   Pfam; PF03349; Toluene_X; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Lipid transport; Membrane; Signal; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..446
FT                   /note="Long-chain fatty acid transport protein"
FT                   /id="PRO_0000025203"
SQ   SEQUENCE   446 AA;  48680 MW;  201486010A16AC40 CRC64;
     MSQKTLFTKS ALAVAVALIS TQAWSAGFQL NEFSSSGLGR AYSGEGAIAD DAGNVSRNPA
     LITMFDRPTF SAGAVYIDPD VDITGHSDLT GQSANAKNIA PTAWVPNLHF VAPINDQFGW
     GASITSNYGL ATEFTDNYAA GIYGGKTDLQ TINLNLSGAY RLNNSWSFGL GFDAVYAKAK
     IERYAGSLGP LLSQQLIAQG VPASLTNGIN TPDSQIAHLK GDEWGFGWNA GILYELDKDN
     RWGLTYRSEV KIDFDGDYKS SINPNLNNIL GNMGLPYGTM GATQNGSLTL NLPEMWEISG
     YNRVAPQWAI HYSMAYTSWS QFQELKAKGD SGQTLFYKDE GFRDAYRIAL GTTYYYDKNW
     TFRTGIAYDD SPVPADKRSI SIPDQDRLWL SAGLTYAFNE DASIDVGASY MHGQKVKFTE
     GEGAAAYSFE SEGKAWLFGT NFNYAF