ID   FADL_SHIFL              Reviewed;         446 AA.
AC   P59741;
DT   20-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 2.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Long-chain fatty acid transport protein;
DE   AltName: Full=Outer membrane FadL protein;
DE   AltName: Full=Outer membrane flp protein;
DE   Flags: Precursor;
GN   Name=fadL; OrderedLocusNames=SF2421, S2557;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Involved in translocation of long-chain fatty acids across
CC       the outer membrane. FadL may form a specific channel (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OmpP1/FadL family. {ECO:0000305}.
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DR   EMBL; AE005674; AAN43932.2; -; Genomic_DNA.
DR   EMBL; AE014073; AAP17746.1; -; Genomic_DNA.
DR   RefSeq; NP_708225.2; NC_004337.2.
DR   RefSeq; WP_005047046.1; NZ_WPGW01000166.1.
DR   AlphaFoldDB; P59741; -.
DR   SMR; P59741; -.
DR   STRING; 198214.SF2421; -.
DR   PRIDE; P59741; -.
DR   EnsemblBacteria; AAN43932; AAN43932; SF2421.
DR   EnsemblBacteria; AAP17746; AAP17746; S2557.
DR   GeneID; 1027343; -.
DR   GeneID; 58388037; -.
DR   KEGG; sfl:SF2421; -.
DR   KEGG; sfx:S2557; -.
DR   PATRIC; fig|198214.7.peg.2892; -.
DR   HOGENOM; CLU_035981_0_0_6; -.
DR   OrthoDB; 620166at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005017; OMPP1/FadL/TodX.
DR   PANTHER; PTHR35093; PTHR35093; 1.
DR   Pfam; PF03349; Toluene_X; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Lipid transport; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..446
FT                   /note="Long-chain fatty acid transport protein"
FT                   /id="PRO_0000025207"
SQ   SEQUENCE   446 AA;  48525 MW;  CE842EBA9621485E CRC64;
     MSQKTLFTKS ALAVAVALIS TQAWSAGFQL NEFSSSGLGR AYSGEGAIAD DAGNVSRNPA
     LITMFDRPTF SAGAVYIDPD VNISGTSPSG RSLKADNIAP TAWVPNMHFV APINDQFGWG
     ASITSNYGLA TEFNDTYAGG SVGGTTDLET MNLNLSGAYR LNNAWSFGLG FNAIYARAKI
     ERFAGDLGQL VAGQIMQSPA GQTPQGQALA ATANGIDSNT KIAHLNGNQW GFGWNAGILY
     ELDKNNRYAL TYRSEVKIDF KGNYSSDLNR AFNNYGLPIP TATGGATQSG YLTLNLPEMW
     EVSGYNRVDP QWAIHYSLAY TSWSQFQQLK ATSTSGDTLF QKHEGFKDAY RIALGTTYYY
     DDNWTFRTGI AFDDSPVPAQ NRSISIPDQD RFWLSAGTTY AFNKDASVDV GVSYMHGQSV
     KINEGPYQFE SEGKAWLFGT NFNYAF