ID   FADR_PECCP              Reviewed;         239 AA.
AC   C6DG46;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Fatty acid metabolism regulator protein {ECO:0000255|HAMAP-Rule:MF_00696};
GN   Name=fadR {ECO:0000255|HAMAP-Rule:MF_00696}; OrderedLocusNames=PC1_1948;
OS   Pectobacterium carotovorum subsp. carotovorum (strain PC1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=561230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PC1;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C.,
RA   Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Balakrishnan V., Glasner J., Perna N.T.;
RT   "Complete sequence of Pectobacterium carotovorum subsp. carotovorum PC1.";
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Multifunctional regulator of fatty acid metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_00696}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00696}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00696}.
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DR   EMBL; CP001657; ACT12989.1; -; Genomic_DNA.
DR   RefSeq; WP_015840182.1; NC_012917.1.
DR   AlphaFoldDB; C6DG46; -.
DR   SMR; C6DG46; -.
DR   STRING; 561230.PC1_1948; -.
DR   EnsemblBacteria; ACT12989; ACT12989; PC1_1948.
DR   KEGG; pct:PC1_1948; -.
DR   eggNOG; COG2186; Bacteria.
DR   HOGENOM; CLU_017584_9_4_6; -.
DR   OMA; WETAGPN; -.
DR   OrthoDB; 1875458at2; -.
DR   Proteomes; UP000002736; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000062; F:fatty-acyl-CoA binding; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0019217; P:regulation of fatty acid metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   HAMAP; MF_00696; HTH_FadR; 1.
DR   InterPro; IPR014178; FA-response_TF_FadR.
DR   InterPro; IPR028374; FadR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR43537:SF10; PTHR43537:SF10; 1.
DR   Pfam; PF07840; FadR_C; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   TIGRFAMs; TIGR02812; fadR_gamma; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Fatty acid metabolism; Lipid metabolism;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..239
FT                   /note="Fatty acid metabolism regulator protein"
FT                   /id="PRO_1000212634"
FT   DOMAIN          6..74
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00696"
FT   DNA_BIND        34..53
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00696"
SQ   SEQUENCE   239 AA;  27080 MW;  CD4C5052A1E77591 CRC64;
     MVIKAQSPAG FAEEYIIESI WNNRFPPGSI LPAERELSEL IGVTRTTLRE VLQRLARDGW
     LTIQHGKPTK INNFWETSGL NILETLARLD HDSVPQLIDN LLAVRTNIAA IFIRTALRHN
     PEKVRDVLTQ ANAVDDSAEA FAQLDYNVFR GLAFASGNPI YGLILNGLKG LYIRVGRYYF
     SNPEARKLAV NFYGRLEALR SEELYDQVMD VVRHYGKESG AIWHSMQSAI PRDIAEVRR