ID   FADR_SALEP              Reviewed;         239 AA.
AC   B5R2W5;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Fatty acid metabolism regulator protein {ECO:0000255|HAMAP-Rule:MF_00696};
GN   Name=fadR {ECO:0000255|HAMAP-Rule:MF_00696}; OrderedLocusNames=SEN1232;
OS   Salmonella enteritidis PT4 (strain P125109).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=550537;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P125109;
RX   PubMed=18583645; DOI=10.1101/gr.077404.108;
RA   Thomson N.R., Clayton D.J., Windhorst D., Vernikos G., Davidson S.,
RA   Churcher C., Quail M.A., Stevens M., Jones M.A., Watson M., Barron A.,
RA   Layton A., Pickard D., Kingsley R.A., Bignell A., Clark L., Harris B.,
RA   Ormond D., Abdellah Z., Brooks K., Cherevach I., Chillingworth T.,
RA   Woodward J., Norberczak H., Lord A., Arrowsmith C., Jagels K., Moule S.,
RA   Mungall K., Saunders M., Whitehead S., Chabalgoity J.A., Maskell D.,
RA   Humphreys T., Roberts M., Barrow P.A., Dougan G., Parkhill J.;
RT   "Comparative genome analysis of Salmonella enteritidis PT4 and Salmonella
RT   gallinarum 287/91 provides insights into evolutionary and host adaptation
RT   pathways.";
RL   Genome Res. 18:1624-1637(2008).
CC   -!- FUNCTION: Multifunctional regulator of fatty acid metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_00696}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00696}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00696}.
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DR   EMBL; AM933172; CAR32812.1; -; Genomic_DNA.
DR   RefSeq; WP_000234826.1; NC_011294.1.
DR   AlphaFoldDB; B5R2W5; -.
DR   SMR; B5R2W5; -.
DR   KEGG; set:SEN1232; -.
DR   HOGENOM; CLU_017584_9_4_6; -.
DR   OMA; WETAGPN; -.
DR   Proteomes; UP000000613; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000062; F:fatty-acyl-CoA binding; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0019217; P:regulation of fatty acid metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   HAMAP; MF_00696; HTH_FadR; 1.
DR   InterPro; IPR014178; FA-response_TF_FadR.
DR   InterPro; IPR028374; FadR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR43537:SF10; PTHR43537:SF10; 1.
DR   Pfam; PF07840; FadR_C; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   TIGRFAMs; TIGR02812; fadR_gamma; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Fatty acid metabolism; Lipid metabolism;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..239
FT                   /note="Fatty acid metabolism regulator protein"
FT                   /id="PRO_1000132326"
FT   DOMAIN          6..74
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00696"
FT   DNA_BIND        34..53
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00696"
SQ   SEQUENCE   239 AA;  26987 MW;  762DEA6A278B2CE4 CRC64;
     MVIKAQSPAG FAEEYIIESI WNNRFPPGTI LPAERELSEL IGVTRTTLRE VLQRLARDGW
     LTIQHGKPTK VNNFWETSGL NILETLARLD HESVPQLIDN LLSVRTNIST IFIRTALRQH
     PDKAQEVLAT AHEVADHADA FADLDYNIFR GLAFASGNPI YGLILNGMKG LYTRIGRHYF
     ANPEARSLAL GFYHKLSSLC EQGAHDQVYE TVRRYGHDSG EIWHRMQKNL PGDLAIQGR