ID   FADR_SALPC              Reviewed;         239 AA.
AC   C0Q329;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Fatty acid metabolism regulator protein {ECO:0000255|HAMAP-Rule:MF_00696};
GN   Name=fadR {ECO:0000255|HAMAP-Rule:MF_00696}; OrderedLocusNames=SPC_1924;
OS   Salmonella paratyphi C (strain RKS4594).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=476213;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RKS4594;
RX   PubMed=19229335; DOI=10.1371/journal.pone.0004510;
RA   Liu W.-Q., Feng Y., Wang Y., Zou Q.-H., Chen F., Guo J.-T., Peng Y.-H.,
RA   Jin Y., Li Y.-G., Hu S.-N., Johnston R.N., Liu G.-R., Liu S.-L.;
RT   "Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis
RT   and pathogenic convergence with Salmonella typhi.";
RL   PLoS ONE 4:E4510-E4510(2009).
CC   -!- FUNCTION: Multifunctional regulator of fatty acid metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_00696}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00696}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00696}.
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DR   EMBL; CP000857; ACN46061.1; -; Genomic_DNA.
DR   RefSeq; WP_000234827.1; NC_012125.1.
DR   AlphaFoldDB; C0Q329; -.
DR   SMR; C0Q329; -.
DR   EnsemblBacteria; ACN46061; ACN46061; SPC_1924.
DR   KEGG; sei:SPC_1924; -.
DR   HOGENOM; CLU_017584_9_4_6; -.
DR   OMA; WETAGPN; -.
DR   Proteomes; UP000001599; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000062; F:fatty-acyl-CoA binding; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0019217; P:regulation of fatty acid metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   HAMAP; MF_00696; HTH_FadR; 1.
DR   InterPro; IPR014178; FA-response_TF_FadR.
DR   InterPro; IPR028374; FadR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR43537:SF10; PTHR43537:SF10; 1.
DR   Pfam; PF07840; FadR_C; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   TIGRFAMs; TIGR02812; fadR_gamma; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Fatty acid metabolism; Lipid metabolism;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..239
FT                   /note="Fatty acid metabolism regulator protein"
FT                   /id="PRO_1000201045"
FT   DOMAIN          6..74
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00696"
FT   DNA_BIND        34..53
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00696"
SQ   SEQUENCE   239 AA;  26977 MW;  752EEA69248B2CE4 CRC64;
     MVIKAQSPAG FAEEYIIESI WNNRFPPGTI LPAERELSEL IGVTRTTLRE VLQRLARDGW
     LTIQHGKPTK VNNFWETSGL NILETLARLD HESVPQLIDN LLSVRTNIST IFIRTALRQH
     PDKAQEVLAT AHEVADHADA FADLDYNIFR GLAFASGNPI YGLILNGMKG LYTRIGRHYF
     ANSEARSLAL GFYHKLSSLC EQGAHDQVYE TVRRYGHDSG EIWHRMQKNL PGDLAIQGR