ID   FADR_SALTI              Reviewed;         239 AA.
AC   Q8Z685;
DT   01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 129.
DE   RecName: Full=Fatty acid metabolism regulator protein {ECO:0000255|HAMAP-Rule:MF_00696};
GN   Name=fadR {ECO:0000255|HAMAP-Rule:MF_00696};
GN   OrderedLocusNames=STY1934, t1072;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Multifunctional regulator of fatty acid metabolism. Represses
CC       transcription of at least eight genes required for fatty acid transport
CC       and beta-oxidation including fadA, fadB, fadD, fadL and fadE. Activates
CC       transcription of at least three genes required for unsaturated fatty
CC       acid biosynthesis: fabA, fabB and iclR, the gene encoding the
CC       transcriptional regulator of the aceBAK operon encoding the glyoxylate
CC       shunt enzymes. Binding of FadR is specifically inhibited by long chain
CC       fatty acyl-CoA compounds (By similarity). {ECO:0000255|HAMAP-
CC       Rule:MF_00696}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00696}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00696}.
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DR   EMBL; AL513382; CAD05488.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO68738.1; -; Genomic_DNA.
DR   RefSeq; NP_456312.1; NC_003198.1.
DR   RefSeq; WP_000234821.1; NZ_WSUR01000004.1.
DR   AlphaFoldDB; Q8Z685; -.
DR   SMR; Q8Z685; -.
DR   STRING; 220341.16502992; -.
DR   EnsemblBacteria; AAO68738; AAO68738; t1072.
DR   KEGG; stt:t1072; -.
DR   KEGG; sty:STY1934; -.
DR   PATRIC; fig|220341.7.peg.1951; -.
DR   eggNOG; COG2186; Bacteria.
DR   HOGENOM; CLU_017584_9_4_6; -.
DR   OMA; WETAGPN; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000062; F:fatty-acyl-CoA binding; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0019217; P:regulation of fatty acid metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   HAMAP; MF_00696; HTH_FadR; 1.
DR   InterPro; IPR014178; FA-response_TF_FadR.
DR   InterPro; IPR028374; FadR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR43537:SF10; PTHR43537:SF10; 1.
DR   Pfam; PF07840; FadR_C; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   TIGRFAMs; TIGR02812; fadR_gamma; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Fatty acid metabolism; Lipid metabolism;
KW   Repressor; Transcription; Transcription regulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..239
FT                   /note="Fatty acid metabolism regulator protein"
FT                   /id="PRO_0000050632"
FT   DOMAIN          6..74
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00696"
FT   DNA_BIND        34..53
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00696"
SQ   SEQUENCE   239 AA;  26934 MW;  2C374BCB3D9A8DF9 CRC64;
     MVIKAQSPAG FAEEYIIESI WNNCFPPGTI LPAERELSEL IGVTRTTLRE VLQRLARDGW
     LTIQHGKPTK VNNFWETSGL NILETLARLD HESVPQLIDN LLSVRTNIST IFIRTALRQH
     PDKAQEVLAT AHEVADHADA FADLDYNIFR GLAFASGNPI YGLILNGMKG LYTRIGRHYF
     ANPEARSLAL GFYHKLSSLC EQGAHDQVYE TVRRYGHDSG EIWHRMQKNL PGDLAIQGR