ID   FADR_SHESR              Reviewed;         241 AA.
AC   Q0HW67;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Fatty acid metabolism regulator protein;
GN   Name=fadR; OrderedLocusNames=Shewmr7_1643;
OS   Shewanella sp. (strain MR-7).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=60481;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MR-7;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nealson K.,
RA   Konstantinidis K., Klappenbach J., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Shewanella sp. MR-7.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Multifunctional regulator of fatty acid metabolism.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
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DR   EMBL; CP000444; ABI42638.1; -; Genomic_DNA.
DR   RefSeq; WP_011625914.1; NC_008322.1.
DR   AlphaFoldDB; Q0HW67; -.
DR   SMR; Q0HW67; -.
DR   EnsemblBacteria; ABI42638; ABI42638; Shewmr7_1643.
DR   KEGG; shm:Shewmr7_1643; -.
DR   HOGENOM; CLU_017584_9_4_6; -.
DR   OMA; WETAGPN; -.
DR   OrthoDB; 1875458at2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000062; F:fatty-acyl-CoA binding; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0019217; P:regulation of fatty acid metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   HAMAP; MF_00696; HTH_FadR; 1.
DR   InterPro; IPR014178; FA-response_TF_FadR.
DR   InterPro; IPR028374; FadR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR43537:SF10; PTHR43537:SF10; 1.
DR   Pfam; PF07840; FadR_C; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   TIGRFAMs; TIGR02812; fadR_gamma; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Fatty acid metabolism; Lipid metabolism;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..241
FT                   /note="Fatty acid metabolism regulator protein"
FT                   /id="PRO_0000301513"
FT   DOMAIN          6..74
FT                   /note="HTH gntR-type"
FT   DNA_BIND        34..53
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   241 AA;  27201 MW;  8E312108617E7343 CRC64;
     MIINAKGPAS FAEKYIVRSI WENKFPPGSI LPAERELSEL IGVTRTTLRE VLQRLARDGW
     LKIQHGKPTR VNNFWETSGL NILETIADLN PEGFPVLVDQ LLSARTNVSA IYFRGALRNS
     PDTAVEVLAQ IHQLEDTAES FAEYDYLLHH TLAFSSGNPL YVLILNGFKG LYSRVGRYYF
     SSSEARQLAL NFYKELEVLA KAKNYVDVPA LMRTYGINSG KMWLQLRDDM PTSIALQEAN
     S