FADR_SHIFL
ID FADR_SHIFL Reviewed; 239 AA.
AC P0A8V9; P09371; P76827;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Fatty acid metabolism regulator protein {ECO:0000255|HAMAP-Rule:MF_00696};
GN Name=fadR {ECO:0000255|HAMAP-Rule:MF_00696};
GN OrderedLocusNames=SF1176, S1264;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Multifunctional regulator of fatty acid metabolism.
CC {ECO:0000255|HAMAP-Rule:MF_00696}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00696}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00696}.
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DR EMBL; AE005674; AAN42791.2; -; Genomic_DNA.
DR EMBL; AE014073; AAP16682.1; -; Genomic_DNA.
DR RefSeq; NP_707084.2; NC_004337.2.
DR RefSeq; WP_000234823.1; NZ_WPGW01000047.1.
DR AlphaFoldDB; P0A8V9; -.
DR SMR; P0A8V9; -.
DR STRING; 198214.SF1176; -.
DR DrugBank; DB01992; Coenzyme A.
DR EnsemblBacteria; AAN42791; AAN42791; SF1176.
DR EnsemblBacteria; AAP16682; AAP16682; S1264.
DR GeneID; 1024109; -.
DR GeneID; 66674993; -.
DR KEGG; sfl:SF1176; -.
DR KEGG; sfx:S1264; -.
DR PATRIC; fig|198214.7.peg.1390; -.
DR HOGENOM; CLU_017584_9_4_6; -.
DR OrthoDB; 1875458at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000062; F:fatty-acyl-CoA binding; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0019217; P:regulation of fatty acid metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.20.120.530; -; 1.
DR HAMAP; MF_00696; HTH_FadR; 1.
DR InterPro; IPR014178; FA-response_TF_FadR.
DR InterPro; IPR028374; FadR_C.
DR InterPro; IPR008920; TF_FadR/GntR_C.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43537:SF10; PTHR43537:SF10; 1.
DR Pfam; PF07840; FadR_C; 1.
DR Pfam; PF00392; GntR; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF48008; SSF48008; 1.
DR TIGRFAMs; TIGR02812; fadR_gamma; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; DNA-binding; Fatty acid metabolism; Lipid metabolism;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..239
FT /note="Fatty acid metabolism regulator protein"
FT /id="PRO_0000050635"
FT DOMAIN 6..74
FT /note="HTH gntR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00696"
FT DNA_BIND 34..53
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00696"
SQ SEQUENCE 239 AA; 26969 MW; 1FECA0DDAD5EB830 CRC64;
MVIKAQSPAG FAEEYIIESI WNNRFPPGTI LPAERELSEL IGVTRTTLRE VLQRLARDGW
LTIQHGKPTK VNNFWETSGL NILETLARLD HESVPQLIDN LLSVRTNIST IFIRTAFRQH
PDKAQEVLAT ANEVADHADA FAELDYNIFR GLAFASGNPI YGLILNGMKG LYTRIGRHYF
ANPEARSLAL GFYHKLSALC SEGAHDQVYE TVRRYGHESG EIWHRMQKNL PGDLAIQGR
