FADR_YERPE
ID FADR_YERPE Reviewed; 239 AA.
AC Q8ZEL9; Q0WF17;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 139.
DE RecName: Full=Fatty acid metabolism regulator protein {ECO:0000255|HAMAP-Rule:MF_00696};
GN Name=fadR {ECO:0000255|HAMAP-Rule:MF_00696};
GN OrderedLocusNames=YPO2144, y2177, YP_1946;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Multifunctional regulator of fatty acid metabolism. Represses
CC transcription of at least eight genes required for fatty acid transport
CC and beta-oxidation including fadA, fadB, fadD, fadL and fadE. Activates
CC transcription of at least three genes required for unsaturated fatty
CC acid biosynthesis: fabA, fabB and iclR, the gene encoding the
CC transcriptional regulator of the aceBAK operon encoding the glyoxylate
CC shunt enzymes. Binding of FadR is specifically inhibited by long chain
CC fatty acyl-CoA compounds (By similarity). {ECO:0000255|HAMAP-
CC Rule:MF_00696}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00696}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00696}.
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DR EMBL; AL590842; CAL20777.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM85739.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS62163.1; -; Genomic_DNA.
DR PIR; AF0261; AF0261.
DR RefSeq; WP_002211688.1; NZ_WUCM01000055.1.
DR RefSeq; YP_002347121.1; NC_003143.1.
DR AlphaFoldDB; Q8ZEL9; -.
DR SMR; Q8ZEL9; -.
DR IntAct; Q8ZEL9; 3.
DR STRING; 214092.YPO2144; -.
DR PaxDb; Q8ZEL9; -.
DR DNASU; 1147124; -.
DR EnsemblBacteria; AAM85739; AAM85739; y2177.
DR EnsemblBacteria; AAS62163; AAS62163; YP_1946.
DR GeneID; 66841495; -.
DR KEGG; ype:YPO2144; -.
DR KEGG; ypk:y2177; -.
DR KEGG; ypm:YP_1946; -.
DR PATRIC; fig|214092.21.peg.2531; -.
DR eggNOG; COG2186; Bacteria.
DR HOGENOM; CLU_017584_9_4_6; -.
DR OMA; WETAGPN; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000062; F:fatty-acyl-CoA binding; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0019217; P:regulation of fatty acid metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.20.120.530; -; 1.
DR HAMAP; MF_00696; HTH_FadR; 1.
DR InterPro; IPR014178; FA-response_TF_FadR.
DR InterPro; IPR028374; FadR_C.
DR InterPro; IPR008920; TF_FadR/GntR_C.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43537:SF10; PTHR43537:SF10; 1.
DR Pfam; PF07840; FadR_C; 1.
DR Pfam; PF00392; GntR; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF48008; SSF48008; 1.
DR TIGRFAMs; TIGR02812; fadR_gamma; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; DNA-binding; Fatty acid metabolism; Lipid metabolism;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..239
FT /note="Fatty acid metabolism regulator protein"
FT /id="PRO_0000050640"
FT DOMAIN 6..74
FT /note="HTH gntR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00696"
FT DNA_BIND 34..53
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00696"
SQ SEQUENCE 239 AA; 26902 MW; 958998E84C0A1D9D CRC64;
MVIKAQSPAG FAEEYIIESI WNNRFPPGSI LPAERELSEL IGVTRTTLRE VLQRLARDGW
LTIQHGKPTK VNNFWETSGL NILETLARLD HDSVPQLIDN LLAVRTNIAT IFVRTAIRHH
PEKAQEILAR AKTVDDNAEA FTALDYGIFR GLAFASGNPI YGLILNGLKG LYTRVGRYYF
SNPEARKLAL TFYNKLSTLC DTESYDQVLE CLRTYGKESG AIWHSMQGTM PSDLAEARR
