FADS6_BOVIN
ID FADS6_BOVIN Reviewed; 342 AA.
AC A2VE15;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Fatty acid desaturase 6;
DE EC=1.14.19.-;
GN Name=FADS6;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; fatty acid metabolism.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family.
CC {ECO:0000305}.
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DR EMBL; BC133520; AAI33521.1; -; mRNA.
DR RefSeq; NP_001075191.1; NM_001081722.1.
DR AlphaFoldDB; A2VE15; -.
DR STRING; 9913.ENSBTAP00000022906; -.
DR PaxDb; A2VE15; -.
DR Ensembl; ENSBTAT00000022906; ENSBTAP00000022906; ENSBTAG00000017242.
DR GeneID; 523867; -.
DR KEGG; bta:523867; -.
DR CTD; 283985; -.
DR VEuPathDB; HostDB:ENSBTAG00000017242; -.
DR VGNC; VGNC:28704; FADS6.
DR eggNOG; ENOG502QQ1J; Eukaryota.
DR GeneTree; ENSGT00950000182990; -.
DR HOGENOM; CLU_047135_0_0_1; -.
DR InParanoid; A2VE15; -.
DR OMA; MFSRDKK; -.
DR OrthoDB; 1379984at2759; -.
DR TreeFam; TF333083; -.
DR UniPathway; UPA00199; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000017242; Expressed in cortex of kidney and 98 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016717; F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; IBA:GO_Central.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IBA:GO_Central.
DR InterPro; IPR005804; FA_desaturase_dom.
DR InterPro; IPR012171; Fatty_acid_desaturase.
DR PANTHER; PTHR19353; PTHR19353; 1.
DR Pfam; PF00487; FA_desaturase; 1.
PE 2: Evidence at transcript level;
KW Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis;
KW Lipid metabolism; Membrane; Oxidoreductase; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..342
FT /note="Fatty acid desaturase 6"
FT /id="PRO_0000341545"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 87..91
FT /note="Histidine box-1"
FT MOTIF 124..128
FT /note="Histidine box-2"
FT MOTIF 277..281
FT /note="Histidine box-3"
SQ SEQUENCE 342 AA; 38614 MW; 84E6519E24D39ADF CRC64;
MEPAGGAPRE SARAEALLGE LEARVQEVVR ASSWWERHGV DCAILALSLL ALPPGFLCLR
SDSPLVFALG ITILGVCHYT LTVKGSHLAT HGALTESRGW SKVWTLFFVE VCTSFTAEYA
KYGHVKMHHG YTNVLGLGDS STWRLPCLNR YVYMFLAPLL IPIITPLVAV ERLREVELRT
ALRTLGLISL GLYSQYWLLL NVSGFQSPSS ALACMLITRS LLAHPYLHVN IFQHIGLPMF
SPDKKPRRIH MMSLGVLNLP RLPVLDWAFG HSLISCHVEH HLFPRLSDNM CLKVKPVVSQ
FLHEKQLPYN EDSYLARFWL FLQRYEEFMV QTPPITELVG LQ
