FADS6_MOUSE
ID FADS6_MOUSE Reviewed; 342 AA.
AC Q80UG1; Q80YA0; Q810B5;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Fatty acid desaturase 6;
DE EC=1.14.19.-;
GN Name=Fads6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
RX PubMed=12588793; DOI=10.1093/hmg/ddg042;
RA Kikkawa Y., Shitara H., Wakana S., Kohara Y., Takada T., Okamoto M.,
RA Taya C., Kamiya K., Yoshikawa Y., Tokano H., Kitamura K., Shimizu K.,
RA Wakabayashi Y., Shiroishi T., Kominami R., Yonekawa H.;
RT "Mutations in a new scaffold protein Sans cause deafness in Jackson shaker
RT mice.";
RL Hum. Mol. Genet. 12:453-461(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 25-342 (ISOFORM 2).
RC TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- PATHWAY: Lipid metabolism; fatty acid metabolism.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q80UG1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80UG1-2; Sequence=VSP_034321;
CC -!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family.
CC {ECO:0000305}.
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DR EMBL; AB087501; BAC57425.1; -; Genomic_DNA.
DR EMBL; AB087503; BAC67683.1; -; mRNA.
DR EMBL; AL603828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC044804; AAH44804.1; -; mRNA.
DR EMBL; BC132041; AAI32042.1; -; mRNA.
DR EMBL; BC132067; AAI32068.1; -; mRNA.
DR CCDS; CCDS25626.1; -. [Q80UG1-1]
DR RefSeq; NP_828874.3; NM_178035.4. [Q80UG1-1]
DR AlphaFoldDB; Q80UG1; -.
DR STRING; 10090.ENSMUSP00000058783; -.
DR iPTMnet; Q80UG1; -.
DR PhosphoSitePlus; Q80UG1; -.
DR EPD; Q80UG1; -.
DR MaxQB; Q80UG1; -.
DR PaxDb; Q80UG1; -.
DR PRIDE; Q80UG1; -.
DR ProteomicsDB; 271719; -. [Q80UG1-1]
DR ProteomicsDB; 271720; -. [Q80UG1-2]
DR Antibodypedia; 63224; 55 antibodies from 14 providers.
DR DNASU; 328035; -.
DR Ensembl; ENSMUST00000056153; ENSMUSP00000058783; ENSMUSG00000044788. [Q80UG1-1]
DR GeneID; 328035; -.
DR KEGG; mmu:328035; -.
DR UCSC; uc007mgz.2; mouse. [Q80UG1-1]
DR CTD; 283985; -.
DR MGI; MGI:3039592; Fads6.
DR VEuPathDB; HostDB:ENSMUSG00000044788; -.
DR eggNOG; ENOG502QQ1J; Eukaryota.
DR GeneTree; ENSGT00950000182990; -.
DR HOGENOM; CLU_047135_0_0_1; -.
DR InParanoid; Q80UG1; -.
DR OMA; MFSRDKK; -.
DR OrthoDB; 1379984at2759; -.
DR PhylomeDB; Q80UG1; -.
DR TreeFam; TF333083; -.
DR UniPathway; UPA00199; -.
DR BioGRID-ORCS; 328035; 4 hits in 77 CRISPR screens.
DR PRO; PR:Q80UG1; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q80UG1; protein.
DR Bgee; ENSMUSG00000044788; Expressed in dorsal pancreas and 164 other tissues.
DR Genevisible; Q80UG1; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016717; F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; IBA:GO_Central.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IBA:GO_Central.
DR InterPro; IPR005804; FA_desaturase_dom.
DR InterPro; IPR012171; Fatty_acid_desaturase.
DR PANTHER; PTHR19353; PTHR19353; 1.
DR Pfam; PF00487; FA_desaturase; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Fatty acid biosynthesis; Fatty acid metabolism;
KW Lipid biosynthesis; Lipid metabolism; Membrane; Oxidoreductase;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..342
FT /note="Fatty acid desaturase 6"
FT /id="PRO_0000341547"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 87..91
FT /note="Histidine box-1"
FT MOTIF 124..128
FT /note="Histidine box-2"
FT MOTIF 277..281
FT /note="Histidine box-3"
FT VAR_SEQ 262..342
FT /note="QLVLDWAFGHSLISCHVEHHLFPWLSDHMCLKVKPLVSKFLHEKQLPYNEDS
FT YLARFQLFLSRYEEFMVHVPPITELVGVQ -> GAPPLPLAL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034321"
FT CONFLICT 29
FT /note="V -> A (in Ref. 1; BAC67683)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 342 AA; 38831 MW; 3C25389B97DC8513 CRC64;
METVRSAPPG DGAAEALLKE LERQVQDVVR ASSWWERHGV DCAILALSLL ALPAGFLCLR
AHNILAFATG ITILGVCHYT LTVKGSHLAT HSALTESKRW SKILMIFFLE VCTAFSAEFA
KFNHVNLHHV YTNVVGLGDS STWKVPLLNR YVYMFLGPLL VPIITPLVAL EHLRKEEPRT
ALRTLGFICL GLYSQYWLFM NVSGFKNPSS ALACMLLTRS LLAHPYLHVN IFQHIGLPMF
SPDKKPRRIH MMTLGVLNLP RQLVLDWAFG HSLISCHVEH HLFPWLSDHM CLKVKPLVSK
FLHEKQLPYN EDSYLARFQL FLSRYEEFMV HVPPITELVG VQ
