ID   FAED_ECOLX              Reviewed;         812 AA.
AC   P06970;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 2.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Outer membrane usher protein FaeD;
DE   Flags: Precursor;
GN   Name=faeD;
OS   Escherichia coli.
OG   Plasmid pFM205.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2870470; DOI=10.1093/nar/14.6.2443;
RA   Mooi F.R., Claassen I., Bakker D., Kuipers H., de Graaf F.K.;
RT   "Regulation and structure of an Escherichia coli gene coding for an outer
RT   membrane protein involved in export of K88ab fimbrial subunits.";
RL   Nucleic Acids Res. 14:2443-2457(1986).
RN   [2]
RP   SEQUENCE REVISION.
RA   Oudega B.;
RL   Submitted (OCT-1990) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8577257; DOI=10.1111/j.1365-2958.1995.tb02346.x;
RA   Valent Q.A., Zaal J., de Graaf F.K., Oudega B.;
RT   "Subcellular localization and topology of the K88 usher FaeD in Escherichia
RT   coli.";
RL   Mol. Microbiol. 16:1243-1257(1995).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 794-812.
RX   PubMed=1713284; DOI=10.1111/j.1365-2958.1991.tb00761.x;
RA   Bakker D., Vader C.E.M., Roosendaal B., Mooi F.R., Oudega B.,
RA   de Graaf F.K.;
RT   "Structure and function of periplasmic chaperone-like proteins involved in
RT   the biosynthesis of K88 and K99 fimbriae in enterotoxigenic Escherichia
RT   coli.";
RL   Mol. Microbiol. 5:875-886(1991).
CC   -!- FUNCTION: Involved in the export and assembly of K88ab fimbrial
CC       subunits across the outer membrane.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the fimbrial export usher family. {ECO:0000305}.
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DR   EMBL; X03675; CAA27310.1; -; Genomic_DNA.
DR   EMBL; X56002; CAA39476.1; -; Genomic_DNA.
DR   EMBL; X56003; CAA39477.1; -; Genomic_DNA.
DR   PIR; S24931; MMECOF.
DR   AlphaFoldDB; P06970; -.
DR   SMR; P06970; -.
DR   TCDB; 1.B.11.1.1; the outer membrane fimbrial usher porin (fup) family.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015473; F:fimbrial usher porin activity; IEA:InterPro.
DR   GO; GO:0009297; P:pilus assembly; IEA:InterPro.
DR   Gene3D; 2.60.40.2610; -; 1.
DR   Gene3D; 3.10.20.410; -; 1.
DR   InterPro; IPR000015; Fimb_usher.
DR   InterPro; IPR018030; Fimbrial_membr_usher_CS.
DR   InterPro; IPR042186; FimD_plug_dom.
DR   InterPro; IPR025885; PapC_N.
DR   InterPro; IPR037224; PapC_N_sf.
DR   PANTHER; PTHR30451; PTHR30451; 1.
DR   Pfam; PF13954; PapC_N; 1.
DR   Pfam; PF00577; Usher; 1.
DR   SUPFAM; SSF141729; SSF141729; 1.
DR   PROSITE; PS01151; FIMBRIAL_USHER; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Disulfide bond; Fimbrium biogenesis; Membrane;
KW   Plasmid; Signal; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..35
FT   CHAIN           36..812
FT                   /note="Outer membrane usher protein FaeD"
FT                   /id="PRO_0000009308"
FT   DISULFID        793..811
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   812 AA;  85497 MW;  C6DAACA4AD88DAFC CRC64;
     MKKYVTTKSV QPVAFRLTTL SLVMSAVLGS ASVIAGEKLD MSFIQGGGGV NPEVWAALNG
     SYAPGRYLVD LSLNGKEAGK QILDVTPQDS NELCLTEAWL TKAGVYVSAD YFREGYDATR
     QCYVLTKAPS VKVDFDVSTQ SLALSIPQKG LVKMPENVDW DYGTSAFRVN YNANANTGRN
     NTSAFGSADL KANIGHWVVS SSATASGGDS GDNSTTINMF TATRAIRALS ADLAVGKTST
     GDSLLGSTGT YGVSLSRNNS MKPGNLGYTP VFSGIANGPS RVTLTQNGRL LHSEMVPAGP
     FSITDVPLYT SGDVTMKITG EDGRDEVQNF PLSVMAGQLS PGQHEFSVAA GLPDDDSDLK
     GGVFAASYGY GLDGLTLRAG GVFNQDWQGA SAGVVAGLGY LGAVSADGAY ATAKYRDGSH
     SGNKVQLSWS KQLETTNTGL RVSWSRQSEE YEGMSSFDPT ELWSQSNHGR RTKDEWNAGI
     SQPVGGLFSL SVSGWQRSYY PASMTGSYRY SDDNGKETGI TGSLSTQIKG VSLNLGWSGS
     RNSRGENNWS ASASVSVPFT LFDRRYSSSA SVSTSKGGGT GFSTGVSGSL NDRFSYGLGG
     GRDGDGGTSS YLNASYSGDR AYLNGVLNHS QSGGTSGSVS VSGSVLAVPA AKDIMFSRTT
     GDTVAVVNVK DTPGVKVTSG DGQTDSDGNL VVPLNSYDWN TVTIDTGTLP LSTELTNTSQ
     KVVPTDKAVV WMPFDALKVK RYLLQVKQRD GEFVPGGTWA RDSKNTPLGF VANNGVLMIN
     TVDAPGDITL GQCRIPAARL QDTEKLQEIT CE