ID   FAEG1_ECOLX             Reviewed;         285 AA.
AC   P02970;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=K88 fimbrial protein AB;
DE   AltName: Full=K88 antigen;
DE   AltName: Full=K88 pilin;
DE   Flags: Precursor;
GN   Name=faeG;
OS   Escherichia coli.
OG   Plasmid pFM205.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Gaastra W., Mooi F.R., Stuitje A.R., de Graaf F.K.;
RT   "The nucleotide sequence of the gene encoding the K88ab protein subunit of
RT   porcine enterotoxigenic Escherichia coli.";
RL   FEMS Microbiol. Lett. 12:41-46(1981).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2412961; DOI=10.1128/iai.50.1.279-283.1985;
RA   Dykes C.W., Halliday I.J., Read M.J., Hobden A.N., Harford S.;
RT   "Nucleotide sequences of four variants of the K88 gene of porcine
RT   enterotoxigenic Escherichia coli.";
RL   Infect. Immun. 50:279-283(1985).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1372075; DOI=10.1111/j.1365-2958.1992.tb02006.x;
RA   Bakker D., Willemsen P.T., Simons L.H., van Zijderveld F.G., de Graaf F.K.;
RT   "Characterization of the antigenic and adhesive properties of FaeG, the
RT   major subunit of K88 fimbriae.";
RL   Mol. Microbiol. 6:247-255(1992).
RN   [4]
RP   PROTEIN SEQUENCE OF 22-185.
RC   STRAIN=D1721;
RX   PubMed=7026236; DOI=10.1111/j.1432-1033.1981.tb06382.x;
RA   Klemm P.;
RT   "The complete amino-acid sequence of the K88 antigen, a fimbrial protein
RT   from Escherichia coli.";
RL   Eur. J. Biochem. 117:617-627(1981).
CC   -!- FUNCTION: K88 major fimbrial subunit. Fimbriae (also called pili), are
CC       polar filaments radiating from the surface of the bacterium to a length
CC       of 0.5-1.5 micrometers and numbering 100-300 per cell. They enable
CC       bacteria to colonize the epithelium of specific host organs.
CC   -!- SUBUNIT: K88 fimbria, 0.1-1 micrometer in length and 7 nanometers in
CC       diameter, is composed of about 100 identical subunits.
CC   -!- SUBCELLULAR LOCATION: Fimbrium.
CC   -!- MISCELLANEOUS: The protein exists in several antigenic variants.
CC   -!- SIMILARITY: Belongs to the fimbrial K88 protein family. {ECO:0000305}.
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DR   EMBL; V00292; CAA23567.1; -; Genomic_DNA.
DR   EMBL; M29374; AAA24032.1; -; Genomic_DNA.
DR   PIR; S07208; YQEC88.
DR   PDB; 4WE2; X-ray; 1.50 A; A=40-285.
DR   PDBsum; 4WE2; -.
DR   AlphaFoldDB; P02970; -.
DR   SMR; P02970; -.
DR   UniLectin; P02970; -.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Fimbrium; Plasmid; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000269|PubMed:7026236"
FT   CHAIN           22..285
FT                   /note="K88 fimbrial protein AB"
FT                   /id="PRO_0000009194"
FT   STRAND          46..50
FT                   /evidence="ECO:0007829|PDB:4WE2"
FT   STRAND          57..60
FT                   /evidence="ECO:0007829|PDB:4WE2"
FT   HELIX           61..63
FT                   /evidence="ECO:0007829|PDB:4WE2"
FT   TURN            66..69
FT                   /evidence="ECO:0007829|PDB:4WE2"
FT   STRAND          70..74
FT                   /evidence="ECO:0007829|PDB:4WE2"
FT   STRAND          79..88
FT                   /evidence="ECO:0007829|PDB:4WE2"
FT   STRAND          101..107
FT                   /evidence="ECO:0007829|PDB:4WE2"
FT   STRAND          127..135
FT                   /evidence="ECO:0007829|PDB:4WE2"
FT   STRAND          141..158
FT                   /evidence="ECO:0007829|PDB:4WE2"
FT   STRAND          163..170
FT                   /evidence="ECO:0007829|PDB:4WE2"
FT   STRAND          187..191
FT                   /evidence="ECO:0007829|PDB:4WE2"
FT   HELIX           195..205
FT                   /evidence="ECO:0007829|PDB:4WE2"
FT   HELIX           210..220
FT                   /evidence="ECO:0007829|PDB:4WE2"
FT   STRAND          226..229
FT                   /evidence="ECO:0007829|PDB:4WE2"
FT   STRAND          241..243
FT                   /evidence="ECO:0007829|PDB:4WE2"
FT   STRAND          245..254
FT                   /evidence="ECO:0007829|PDB:4WE2"
FT   STRAND          259..266
FT                   /evidence="ECO:0007829|PDB:4WE2"
FT   STRAND          272..275
FT                   /evidence="ECO:0007829|PDB:4WE2"
FT   STRAND          278..284
FT                   /evidence="ECO:0007829|PDB:4WE2"
SQ   SEQUENCE   285 AA;  29546 MW;  8ABBF6EC16616450 CRC64;
     MKKTLIALAI AASAASGMAH AWMTGDFNGS VDIGGSITAD DYRQKWEWKV GTGLNGFGNV
     LNDLTNGGTK LTITVTGNKP ILLGRTKEAF ATPVSGGVDG IPQIAFTDYE GASVKLRNTD
     GETNKGLAYF VLPMKNAEGT KVGSVKVNAS YAGVFGKGGV TSADGELFSL FADGLRAIFY
     GGLTTTVSGA ALTSGSAAAA RTELFGSLSR NDILGQIQRV NANITSLVDV AGSYREDMEY
     TDGTVVSAAY ALGIANGQTI EATFNQAVTT STQWSAPLNV AITYY