FAEG2_ECOLX
ID FAEG2_ECOLX Reviewed; 283 AA.
AC P14190;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=K88 fimbrial protein AC;
DE AltName: Full=K88 antigen;
DE AltName: Full=K88 pilin;
DE Flags: Precursor;
GN Name=faeG;
OS Escherichia coli.
OG Plasmid pFM205.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2412961; DOI=10.1128/iai.50.1.279-283.1985;
RA Dykes C.W., Halliday I.J., Read M.J., Hobden A.N., Harford S.;
RT "Nucleotide sequences of four variants of the K88 gene of porcine
RT enterotoxigenic Escherichia coli.";
RL Infect. Immun. 50:279-283(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX AGRICOLA=IND85004943;
RA Josephsen J., Hansen F., de Graaf F.K., Gaastra W.;
RT "The nucleotide sequence of the protein subunit of the K88ac fimbriae of
RT porcine enterotoxigenic Escherichia coli.";
RL FEMS Microbiol. Lett. 25:301-306(1984).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2471451; DOI=10.1128/aem.55.4.984-993.1989;
RA Thiry G., Clippe A., Scarcez T., Petre J.;
RT "Cloning of DNA sequences encoding foreign peptides and their expression in
RT the K88 pili.";
RL Appl. Environ. Microbiol. 55:984-993(1989).
CC -!- FUNCTION: K88 major fimbrial subunit. Fimbriae (also called pili), are
CC polar filaments radiating from the surface of the bacterium to a length
CC of 0.5-1.5 micrometers and numbering 100-300 per cell. They enable
CC bacteria to colonize the epithelium of specific host organs.
CC -!- SUBUNIT: K88 fimbria, 0.1-1 micrometer in length and 7 nanometers in
CC diameter, is composed of about 100 identical subunits.
CC -!- SUBCELLULAR LOCATION: Fimbrium.
CC -!- MISCELLANEOUS: The protein exists in several antigenic variants.
CC -!- SIMILARITY: Belongs to the fimbrial K88 protein family. {ECO:0000305}.
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DR EMBL; M29375; AAA24033.1; -; Genomic_DNA.
DR EMBL; M35954; AAA24034.1; -; Genomic_DNA.
DR EMBL; M25302; AAA24390.1; -; Genomic_DNA.
DR EMBL; A02560; CAA00254.1; -; Unassigned_DNA.
DR PIR; I41318; I41318.
DR RefSeq; WP_063096999.1; NZ_NNVI01000068.1.
DR PDB; 2J6R; X-ray; 1.90 A; A/B=22-283.
DR PDB; 4WEM; X-ray; 1.55 A; A=40-283.
DR PDB; 4WEN; X-ray; 1.89 A; A=40-283.
DR PDBsum; 2J6R; -.
DR PDBsum; 4WEM; -.
DR PDBsum; 4WEN; -.
DR AlphaFoldDB; P14190; -.
DR SMR; P14190; -.
DR ABCD; P14190; 9 sequenced antibodies.
DR EvolutionaryTrace; P14190; -.
DR GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW 3D-structure; Fimbrium; Plasmid; Signal.
FT SIGNAL 1..21
FT CHAIN 22..283
FT /note="K88 fimbrial protein AC"
FT /id="PRO_0000009195"
FT CONFLICT 178
FT /note="S -> A (in Ref. 2; AAA24034)"
FT /evidence="ECO:0000305"
FT CONFLICT 190
FT /note="L -> S (in Ref. 2; AAA24034)"
FT /evidence="ECO:0000305"
FT STRAND 23..26
FT /evidence="ECO:0007829|PDB:2J6R"
FT STRAND 28..31
FT /evidence="ECO:0007829|PDB:2J6R"
FT STRAND 33..38
FT /evidence="ECO:0007829|PDB:2J6R"
FT STRAND 46..51
FT /evidence="ECO:0007829|PDB:4WEM"
FT STRAND 57..60
FT /evidence="ECO:0007829|PDB:4WEM"
FT HELIX 61..63
FT /evidence="ECO:0007829|PDB:4WEM"
FT TURN 66..69
FT /evidence="ECO:0007829|PDB:4WEM"
FT STRAND 70..74
FT /evidence="ECO:0007829|PDB:4WEM"
FT STRAND 79..88
FT /evidence="ECO:0007829|PDB:4WEM"
FT STRAND 94..98
FT /evidence="ECO:0007829|PDB:2J6R"
FT STRAND 101..107
FT /evidence="ECO:0007829|PDB:4WEM"
FT STRAND 128..136
FT /evidence="ECO:0007829|PDB:4WEM"
FT STRAND 142..159
FT /evidence="ECO:0007829|PDB:4WEM"
FT STRAND 164..171
FT /evidence="ECO:0007829|PDB:4WEM"
FT STRAND 186..188
FT /evidence="ECO:0007829|PDB:4WEM"
FT HELIX 193..203
FT /evidence="ECO:0007829|PDB:4WEM"
FT HELIX 208..216
FT /evidence="ECO:0007829|PDB:4WEM"
FT STRAND 224..227
FT /evidence="ECO:0007829|PDB:4WEM"
FT STRAND 239..241
FT /evidence="ECO:0007829|PDB:4WEM"
FT STRAND 243..252
FT /evidence="ECO:0007829|PDB:4WEM"
FT STRAND 257..264
FT /evidence="ECO:0007829|PDB:4WEM"
FT STRAND 270..273
FT /evidence="ECO:0007829|PDB:4WEM"
FT STRAND 276..282
FT /evidence="ECO:0007829|PDB:4WEM"
SQ SEQUENCE 283 AA; 29377 MW; E3DD8516135CEC7F CRC64;
MKKTLIALAI AASAASGMAH AWMTGDFNGS VDIGGSITAD DYRQKWEWKV GTGLNGFGNV
LNDLTNGGTK LTITVTGNKP ILLGRTKEAF ATPVTGGVDG IPHIAFTDYE GASVVLRNPD
GETNKKGLAY FVLPMKNAEG TKVGSVKVNA SYAGVLGRGG VTSADGELLS LFADGLSSIF
YGGLPRGSEL SAGSAAAART KLFGSLSRND ILGQIQRVNA NITSLVDVAG SYRENMEYTD
GTVVSAAYAL GIANGQTIEA TFNQAVTTST QWSAPLNVAI TYY
