FAF1_ARATH
ID FAF1_ARATH Reviewed; 271 AA.
AC Q9SY06; Q6NKQ3;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Protein FANTASTIC FOUR 1;
GN Name=FAF1; OrderedLocusNames=At4g02810; ORFNames=T5J8.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Cheuk R., Kim C.J., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA Takagi M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=21176196; DOI=10.1186/1471-2229-10-285;
RA Wahl V., Brand L.H., Guo Y.L., Schmid M.;
RT "The FANTASTIC FOUR proteins influence shoot meristem size in Arabidopsis
RT thaliana.";
RL BMC Plant Biol. 10:285-285(2010).
CC -!- FUNCTION: Able to repress WUS when constitutively overexpressed, but
CC have no effect on CLV3. {ECO:0000269|PubMed:21176196}.
CC -!- TISSUE SPECIFICITY: Expressed in the shoot apex, stamens, anthers and
CC young siliques. Detected in provascular and vascular tissue.
CC {ECO:0000269|PubMed:21176196}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout development. During
CC germination, initially restricted to the hypocotyl, but expression
CC gradually shifts to the root and on day 6, to the vasculature of the
CC cotyledons and then of the leaves. Increased expression in the shoot
CC apex during the transition to flowering. Induced in the inflorescence
CC vasculature and young flower buds as flowering commenced. Expressed in
CC developing embryos from the early heart stage until torpedo stage.
CC {ECO:0000269|PubMed:21176196}.
CC -!- SIMILARITY: Belongs to the fantastic four family. {ECO:0000305}.
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DR EMBL; AC004044; AAD15352.1; -; Genomic_DNA.
DR EMBL; AL161495; CAB77766.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE82232.1; -; Genomic_DNA.
DR EMBL; BT012641; AAT06460.1; -; mRNA.
DR EMBL; AK176321; BAD44084.1; -; mRNA.
DR EMBL; AB493673; BAH30511.1; -; Genomic_DNA.
DR PIR; G85035; G85035.
DR RefSeq; NP_192190.1; NM_116515.4.
DR AlphaFoldDB; Q9SY06; -.
DR BioGRID; 13459; 3.
DR STRING; 3702.AT4G02810.1; -.
DR PaxDb; Q9SY06; -.
DR PRIDE; Q9SY06; -.
DR EnsemblPlants; AT4G02810.1; AT4G02810.1; AT4G02810.
DR GeneID; 828170; -.
DR Gramene; AT4G02810.1; AT4G02810.1; AT4G02810.
DR KEGG; ath:AT4G02810; -.
DR Araport; AT4G02810; -.
DR TAIR; locus:2140205; AT4G02810.
DR eggNOG; ENOG502RYS2; Eukaryota.
DR HOGENOM; CLU_053779_0_0_1; -.
DR InParanoid; Q9SY06; -.
DR OMA; CFVSERR; -.
DR OrthoDB; 1294944at2759; -.
DR PhylomeDB; Q9SY06; -.
DR PRO; PR:Q9SY06; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9SY06; baseline and differential.
DR Genevisible; Q9SY06; AT.
DR InterPro; IPR021410; FAF.
DR PANTHER; PTHR33155; PTHR33155; 2.
DR Pfam; PF11250; FAF; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..271
FT /note="Protein FANTASTIC FOUR 1"
FT /id="PRO_0000405260"
FT DOMAIN 114..168
FT /note="FAF"
FT REGION 174..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..227
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..253
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 223
FT /note="E -> G (in Ref. 3; AAT06460 and 4; BAD44084)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 271 AA; 31197 MW; E2985FA5CD63B504 CRC64;
MSIVVGQAYQ HLPKQVSQNP DVGGWSFLQY FSEPKGIVQN REDDTKKTAY VYPIEKRSVA
KLSLEMCTES LGTENGSDSG DEMSLLALEA TNISKSPRLT TKPQKETSFM TRENSFPPPL
NSVNGFNNSR MVKSYKEDGR LVVQAIRVCS PPRCFVSERR EGRLRLCLSQ NSLNSQDAEE
EFEEEDEDDQ YDAEEEEEEE EEEEEEEEEE EEEEEEEEEE DEEGIVGNNE NFEGKSGNKK
VSNRPKRRCN ENGCEPKTML NWKQQQFWVT T
