ID   FAF1_ASCSU              Reviewed;           7 AA.
AC   P31889;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   11-DEC-2019, entry version 38.
DE   RecName: Full=FMRFamide-like neuropeptide AF1;
OS   Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX   NCBI_TaxID=6253;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT PHE-7.
RX   PubMed=2627377; DOI=10.1016/0896-6273(89)90192-x;
RA   Cowden C., Stretton A.O.W., Davis R.E.;
RT   "AF1, a sequenced bioactive neuropeptide isolated from the nematode Ascaris
RT   suum.";
RL   Neuron 2:1465-1473(1989).
CC   -!- FUNCTION: Potent modulator of inhibitory motorneurons. Reduces the
CC       input resistance and blocks slow oscillatory potentials in these cells.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Found in the nerve cords and a variety of ganglia
CC       particularly in the anterior regions.
CC   -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT   PEPTIDE         1..7
FT                   /note="FMRFamide-like neuropeptide AF1"
FT                   /id="PRO_0000043655"
FT   MOD_RES         7
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:2627377"
SQ   SEQUENCE   7 AA;  953 MW;  69D40059CB144350 CRC64;
     KNEFIRF