FAF2_ARATH
ID FAF2_ARATH Reviewed; 240 AA.
AC Q8GXU9; Q9ZVR9;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Protein FANTASTIC FOUR 2;
GN Name=FAF2; OrderedLocusNames=At1g03170; ORFNames=F15K9.21, F15K9.22;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=21176196; DOI=10.1186/1471-2229-10-285;
RA Wahl V., Brand L.H., Guo Y.L., Schmid M.;
RT "The FANTASTIC FOUR proteins influence shoot meristem size in Arabidopsis
RT thaliana.";
RL BMC Plant Biol. 10:285-285(2010).
CC -!- FUNCTION: Regulates the size of the shoot meristem by modulating the
CC CLV3-WUS feedback loop. Can repress WUS but is under negative control
CC by CLV3. {ECO:0000269|PubMed:21176196}.
CC -!- TISSUE SPECIFICITY: Expressed in the shoot apex, stamens, carpels and
CC young siliques. Detected in provascular and vascular tissue, and in the
CC center of the vegetative and inflorescence meristems. Expressed in the
CC funiculus. In roots and leaves, predominantly expressed in phloem.
CC {ECO:0000269|PubMed:21176196}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout development. Increased
CC expression in the shoot apex during the transition to flowering.
CC Induced in the inflorescence vasculature and young flower buds as
CC flowering commenced. {ECO:0000269|PubMed:21176196}.
CC -!- SIMILARITY: Belongs to the fantastic four family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC72118.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAM65050.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC005278; AAC72118.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE27539.1; -; Genomic_DNA.
DR EMBL; AK118027; BAC42659.1; -; mRNA.
DR EMBL; AY087507; AAM65050.1; ALT_INIT; mRNA.
DR PIR; A86163; A86163.
DR RefSeq; NP_563678.1; NM_100199.2.
DR AlphaFoldDB; Q8GXU9; -.
DR STRING; 3702.AT1G03170.1; -.
DR PaxDb; Q8GXU9; -.
DR PRIDE; Q8GXU9; -.
DR EnsemblPlants; AT1G03170.1; AT1G03170.1; AT1G03170.
DR GeneID; 839563; -.
DR Gramene; AT1G03170.1; AT1G03170.1; AT1G03170.
DR KEGG; ath:AT1G03170; -.
DR Araport; AT1G03170; -.
DR TAIR; locus:2014560; AT1G03170.
DR HOGENOM; CLU_053779_0_0_1; -.
DR InParanoid; Q8GXU9; -.
DR OMA; SKYNRMV; -.
DR OrthoDB; 1294944at2759; -.
DR PhylomeDB; Q8GXU9; -.
DR PRO; PR:Q8GXU9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8GXU9; baseline and differential.
DR Genevisible; Q8GXU9; AT.
DR GO; GO:0010075; P:regulation of meristem growth; IMP:UniProtKB.
DR InterPro; IPR021410; FAF.
DR PANTHER; PTHR33155; PTHR33155; 1.
DR Pfam; PF11250; FAF; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..240
FT /note="Protein FANTASTIC FOUR 2"
FT /id="PRO_0000405261"
FT DOMAIN 117..171
FT /note="FAF"
FT REGION 89..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..198
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 240 AA; 27255 MW; 09F9C22CE76E1108 CRC64;
MSLVVCQPQI NESFYQKDDM GGLSFLQSMS DITSIAQTKE DKAYVHPMEK RSVSKLNEKS
LEMCTESLGT ETGSESGDEL SLLAFEATTT PRAPPRQLKP QEDTNLPDKT PPMSRNNSFP
PPIKFVEDSK YNRMVRWLGE DGRIVVQAIR VSSPPSCFVS ERGEGRLRLI LTSESSLLSH
NHEEEEEEET EEGIDEETSE NLEGKSGNKK FSRFSRRCKE NGREPKPMLT WKQQQFWVAT
