FAF4_ARATH
ID FAF4_ARATH Reviewed; 300 AA.
AC Q9SFG6;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Protein FANTASTIC FOUR 4;
GN Name=FAF4; OrderedLocusNames=At3g06020; ORFNames=F2O10.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION, DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=21176196; DOI=10.1186/1471-2229-10-285;
RA Wahl V., Brand L.H., Guo Y.L., Schmid M.;
RT "The FANTASTIC FOUR proteins influence shoot meristem size in Arabidopsis
RT thaliana.";
RL BMC Plant Biol. 10:285-285(2010).
CC -!- FUNCTION: Regulates the size of the shoot meristem by modulating the
CC CLV3-WUS feedback loop. Can repress WUS but is under negative control
CC by CLV3. {ECO:0000269|PubMed:21176196}.
CC -!- TISSUE SPECIFICITY: Expressed in the shoot apex and young siliques.
CC Detected in provascular and vascular tissue, but not in the vegetative
CC meristem. In inflorescences, restricted to the base of the flower and
CC to the vasculature of the stem and the pedicels, but absent from young
CC flowers. Detected in the center of the inflorescence meristem.
CC {ECO:0000269|PubMed:21176196}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout development. Decreased
CC expression in the shoot apex during the transition to flowering.
CC Expressed in developing embryos from the early heart stage until
CC torpedo stage. {ECO:0000269|PubMed:21176196}.
CC -!- SIMILARITY: Belongs to the fantastic four family. {ECO:0000305}.
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DR EMBL; AC013454; AAF23215.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74331.1; -; Genomic_DNA.
DR RefSeq; NP_187253.1; NM_111476.2.
DR AlphaFoldDB; Q9SFG6; -.
DR STRING; 3702.AT3G06020.1; -.
DR PaxDb; Q9SFG6; -.
DR PRIDE; Q9SFG6; -.
DR EnsemblPlants; AT3G06020.1; AT3G06020.1; AT3G06020.
DR GeneID; 819773; -.
DR Gramene; AT3G06020.1; AT3G06020.1; AT3G06020.
DR KEGG; ath:AT3G06020; -.
DR Araport; AT3G06020; -.
DR TAIR; locus:2083008; AT3G06020.
DR eggNOG; ENOG502QVU6; Eukaryota.
DR HOGENOM; CLU_053779_0_0_1; -.
DR InParanoid; Q9SFG6; -.
DR OMA; NRCLQDR; -.
DR OrthoDB; 1294944at2759; -.
DR PhylomeDB; Q9SFG6; -.
DR PRO; PR:Q9SFG6; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SFG6; baseline and differential.
DR Genevisible; Q9SFG6; AT.
DR GO; GO:0010075; P:regulation of meristem growth; IMP:UniProtKB.
DR InterPro; IPR021410; FAF.
DR PANTHER; PTHR33155; PTHR33155; 1.
DR Pfam; PF11250; FAF; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..300
FT /note="Protein FANTASTIC FOUR 4"
FT /id="PRO_0000405263"
FT DOMAIN 166..217
FT /note="FAF"
FT REGION 30..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..260
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 300 AA; 33895 MW; A1DDDD3D11F190A8 CRC64;
MATVVYQSYF ESQHFEPRAL RLRLSSHTNP QLSTPLKSHF QNSSIAPQDN PITINAASLP
SSSPNPSSNS DTNSGSWSFL ESLSNSSSND KEKKTLPLFQ SPSSRRTLSD ESLALCTESL
GSETGSDIIH EDMFSISSEL QTMETRTTST TSNPSRQDRK RNTMASLPPP LTSMIGFDCI
EVKSHRENGR LVMMATRPPP RNRCLQDRSN GCVRLAILID SDDHIETETK EEKEEEEEET
IETVRDNEEE IPEYKEEEEE KEEEIKVKGV EKVQRSRRCI EGDRENRGFL NWESLCVATS
