FAHD1_CAEEL
ID FAHD1_CAEEL Reviewed; 214 AA.
AC P34673;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Fumarylacetoacetate hydrolase domain-containing protein 1 {ECO:0000312|WormBase:ZK688.3};
DE EC=3.-.-.- {ECO:0000305};
GN Name=fahd-1 {ECO:0000312|WormBase:ZK688.3};
GN ORFNames=ZK688.3 {ECO:0000312|WormBase:ZK688.3};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: May have hydrolase activity. {ECO:0000250|UniProtKB:Q6P587}.
CC -!- SIMILARITY: Belongs to the FAH family. {ECO:0000305}.
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DR EMBL; FO080277; CCD62534.1; -; Genomic_DNA.
DR PIR; S44919; S44919.
DR RefSeq; NP_498715.1; NM_066314.5.
DR AlphaFoldDB; P34673; -.
DR SMR; P34673; -.
DR BioGRID; 41316; 4.
DR DIP; DIP-25035N; -.
DR STRING; 6239.ZK688.3.2; -.
DR EPD; P34673; -.
DR PaxDb; P34673; -.
DR PeptideAtlas; P34673; -.
DR EnsemblMetazoa; ZK688.3.1; ZK688.3.1; WBGene00022798.
DR EnsemblMetazoa; ZK688.3.2; ZK688.3.2; WBGene00022798.
DR GeneID; 176109; -.
DR KEGG; cel:CELE_ZK688.3; -.
DR UCSC; ZK688.3.1; c. elegans.
DR CTD; 176109; -.
DR WormBase; ZK688.3; CE00461; WBGene00022798; fahd-1.
DR eggNOG; KOG1535; Eukaryota.
DR GeneTree; ENSGT00940000160452; -.
DR HOGENOM; CLU_028458_5_0_1; -.
DR InParanoid; P34673; -.
DR OMA; YALSIDM; -.
DR OrthoDB; 1216556at2759; -.
DR PhylomeDB; P34673; -.
DR Reactome; R-CEL-71403; Citric acid cycle (TCA cycle).
DR PRO; PR:P34673; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00022798; Expressed in larva and 4 other tissues.
DR GO; GO:0005739; C:mitochondrion; IDA:WormBase.
DR GO; GO:0018773; F:acetylpyruvate hydrolase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.90.850.10; -; 1.
DR InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR Pfam; PF01557; FAA_hydrolase; 1.
DR SUPFAM; SSF56529; SSF56529; 1.
PE 3: Inferred from homology;
KW Hydrolase; Metal-binding; Reference proteome.
FT CHAIN 1..214
FT /note="Fumarylacetoacetate hydrolase domain-containing
FT protein 1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000156841"
FT BINDING 65
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000250|UniProtKB:Q6P587"
FT BINDING 67
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000250|UniProtKB:Q6P587"
FT BINDING 96
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000250|UniProtKB:Q6P587"
SQ SEQUENCE 214 AA; 23335 MW; 4C0CCE6E3065D007 CRC64;
MSSLAGFRNL ATKIVCVGRN YKDHALELGN AIPKKPMLFV KTVNSFIVEG EPIVAPPGCQ
NLHQEVELGV VISKKASRIS KSDAMDYIGG YTVALDMTAR DFQDEAKKAG APWFLAKSFD
GSCPIGGFLP VSDIPNPHDV ELFCKINGKD QQRCRTDVMI FDIPTLLEYT TQFFTLEVGD
VVLTGTPAGV TKINSGDVIE FGLTDKLNSK FNVQ
