ID   FAHD2_BOVIN             Reviewed;         314 AA.
AC   Q2KIB0; Q6Y1E3;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Fumarylacetoacetate hydrolase domain-containing protein 2;
DE            EC=3.-.-.-;
GN   Name=FAHD2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Korean;
RA   Baik M., Bong J.;
RT   "Nucleotide sequence of bovine CGI-105 protein cDNA in adipose tissues of
RT   Korean cattle (Hanwoo).";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May have hydrolase activity. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000305};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000305};
CC   -!- SIMILARITY: Belongs to the FAH family. {ECO:0000305}.
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DR   EMBL; AY192436; AAP33277.1; -; mRNA.
DR   EMBL; BC112705; AAI12706.1; -; mRNA.
DR   RefSeq; NP_991359.1; NM_205790.1.
DR   AlphaFoldDB; Q2KIB0; -.
DR   SMR; Q2KIB0; -.
DR   STRING; 9913.ENSBTAP00000015354; -.
DR   PaxDb; Q2KIB0; -.
DR   PeptideAtlas; Q2KIB0; -.
DR   PRIDE; Q2KIB0; -.
DR   GeneID; 404123; -.
DR   KEGG; bta:404123; -.
DR   CTD; 51011; -.
DR   eggNOG; KOG1535; Eukaryota.
DR   InParanoid; Q2KIB0; -.
DR   OrthoDB; 1216556at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016836; F:hydro-lyase activity; IBA:GO_Central.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.850.10; -; 1.
DR   InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR   InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR   Pfam; PF01557; FAA_hydrolase; 1.
DR   SUPFAM; SSF56529; SSF56529; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Calcium; Hydrolase; Magnesium; Metal-binding;
KW   Reference proteome.
FT   CHAIN           1..314
FT                   /note="Fumarylacetoacetate hydrolase domain-containing
FT                   protein 2"
FT                   /id="PRO_0000289794"
FT   BINDING         159
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P587"
FT   BINDING         161
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P587"
FT   BINDING         190
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P587"
FT   MOD_RES         203
FT                   /note="N6-acetyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q3TC72"
FT   MOD_RES         203
FT                   /note="N6-succinyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q3TC72"
FT   MOD_RES         234
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3TC72"
FT   CONFLICT        155
FT                   /note="E -> K (in Ref. 1; AAP33277)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        243
FT                   /note="L -> V (in Ref. 1; AAP33277)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   314 AA;  34556 MW;  E5C7B8681465259C CRC64;
     MLGSSGRRLL TTVLQAQRWP FQPSRDMRLV QFQAPHLAGP HLGLESGNGG GVIDLNAFEP
     TLPKTMVEFL EQGEATLSVV RRALATQLPV LPRSEVTFLA PVTRPDKVVC VGMNYADHCR
     EQNVPVPKEP IIFSKFASAI VGPYDNIILP PESQEVDWEV ELAVVIGKRG KYIKATDAMA
     HVAGFTVAHD VSARDWQMGR NGKQWLLGKT FDTFCPLGPA LVTKDSVADP HNLKICCRVN
     GELMQSSNTN QMVFKTEELI TWVSQFVTLY PGDIILTGTP PGVGVFRKPP VFLKKGDEVQ
     CEIEELGVII NKVV