ID   FAHD2_DICDI             Reviewed;         305 AA.
AC   Q54BF3;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Fumarylacetoacetate hydrolase domain-containing protein 2 homolog;
DE            EC=3.-.-.-;
GN   Name=fahd2; ORFNames=DDB_G0293650;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May have hydrolase activity. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000305};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000305};
CC   -!- SIMILARITY: Belongs to the FAH family. {ECO:0000305}.
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DR   EMBL; AAFI02000218; EAL60637.1; -; Genomic_DNA.
DR   RefSeq; XP_629076.1; XM_629074.1.
DR   AlphaFoldDB; Q54BF3; -.
DR   SMR; Q54BF3; -.
DR   STRING; 44689.DDB0237519; -.
DR   PaxDb; Q54BF3; -.
DR   EnsemblProtists; EAL60637; EAL60637; DDB_G0293650.
DR   GeneID; 8629368; -.
DR   KEGG; ddi:DDB_G0293650; -.
DR   dictyBase; DDB_G0293650; fahd2.
DR   eggNOG; KOG1535; Eukaryota.
DR   HOGENOM; CLU_028458_3_2_1; -.
DR   InParanoid; Q54BF3; -.
DR   OMA; PPEPIIF; -.
DR   PhylomeDB; Q54BF3; -.
DR   PRO; PR:Q54BF3; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0016836; F:hydro-lyase activity; IBA:GO_Central.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.850.10; -; 1.
DR   InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR   InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR   Pfam; PF01557; FAA_hydrolase; 1.
DR   SUPFAM; SSF56529; SSF56529; 1.
PE   3: Inferred from homology;
KW   Calcium; Hydrolase; Magnesium; Metal-binding; Reference proteome.
FT   CHAIN           1..305
FT                   /note="Fumarylacetoacetate hydrolase domain-containing
FT                   protein 2 homolog"
FT                   /id="PRO_0000328491"
FT   BINDING         141
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P587"
FT   BINDING         143
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P587"
FT   BINDING         172
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P587"
SQ   SEQUENCE   305 AA;  33671 MW;  47ED08D21204CD05 CRC64;
     MNRANFGLIK LVTYIPNVGE QSKRLGALLE NSIIDLCSAD KSIPNDMRSF LSLNSTDKWS
     KVINVINNIN NRRIPIENCK IKAPIEPGKI ICIGLNYKEH ANEAKMAIPK EPIVFSKFDN
     AICGPNDSII KPVESDEVDY EVELVVVIGK QAKNVSESDA LQYVAGYTVG NDVSARDWQL
     RKNNSQWLLG KTFDTFAPIG PSIVINPEVA ALSDDTYFDP NNLSIKCTLN GQVVQNSTTK
     EFIFNIQTVV SYLSKLFTLN PGDIIFTGTP SGVGFIRKPN PIFLKSGDVI KCEIEELGSL
     VNNVK