FAHD2_ORYSJ
ID FAHD2_ORYSJ Reviewed; 226 AA.
AC Q10B63; Q850X1; Q8SAY6;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Probable acylpyruvase FAHD2, mitochondrial {ECO:0000305};
DE EC=3.7.1.5 {ECO:0000305};
DE AltName: Full=Fumarylacetoacetate hydrolase domain-containing protein 2 {ECO:0000305};
DE Short=FAH domain-containing protein 2 {ECO:0000305};
DE Flags: Precursor;
GN Name=FAHD2 {ECO:0000305};
GN OrderedLocusNames=Os03g0829000 {ECO:0000312|EMBL:BAF13693.1},
GN LOC_Os03g61330 {ECO:0000312|EMBL:ABF99681.1};
GN ORFNames=OsJ_13211 {ECO:0000312|EMBL:EAZ29150.1},
GN OSJNBa0010E04.1 {ECO:0000312|EMBL:AAL79746.1},
GN OSJNBb0027B08.34 {ECO:0000312|EMBL:AAO39866.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16109971; DOI=10.1101/gr.3869505;
RG The rice chromosome 3 sequencing consortium;
RA Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA Jin W., Lee H.R., Jiang J., Jackson S.;
RT "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT and diverged grass species.";
RL Genome Res. 15:1284-1291(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
CC -!- FUNCTION: Probable acylpyruvase. {ECO:0000250|UniProtKB:Q93ZE5}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 3-acylpyruvate + H2O = a carboxylate + H(+) + pyruvate;
CC Xref=Rhea:RHEA:19009, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:57278; EC=3.7.1.5;
CC Evidence={ECO:0000305};
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the FAH family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO39866.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC096687; AAL79746.1; -; Genomic_DNA.
DR EMBL; AC133778; AAO39866.1; ALT_SEQ; Genomic_DNA.
DR EMBL; DP000009; ABF99681.1; -; Genomic_DNA.
DR EMBL; DP000009; ABF99682.1; -; Genomic_DNA.
DR EMBL; AP008209; BAF13693.1; -; Genomic_DNA.
DR EMBL; AP014959; BAS87180.1; -; Genomic_DNA.
DR EMBL; CM000140; EAZ29150.1; -; Genomic_DNA.
DR RefSeq; XP_015628291.1; XM_015772805.1.
DR RefSeq; XP_015628292.1; XM_015772806.1.
DR AlphaFoldDB; Q10B63; -.
DR SMR; Q10B63; -.
DR STRING; 4530.OS03T0829000-01; -.
DR PaxDb; Q10B63; -.
DR PRIDE; Q10B63; -.
DR EnsemblPlants; Os03t0829000-01; Os03t0829000-01; Os03g0829000.
DR EnsemblPlants; Os03t0829000-02; Os03t0829000-02; Os03g0829000.
DR EnsemblPlants; Os03t0829000-03; Os03t0829000-03; Os03g0829000.
DR GeneID; 4334655; -.
DR Gramene; Os03t0829000-01; Os03t0829000-01; Os03g0829000.
DR Gramene; Os03t0829000-02; Os03t0829000-02; Os03g0829000.
DR Gramene; Os03t0829000-03; Os03t0829000-03; Os03g0829000.
DR KEGG; osa:4334655; -.
DR eggNOG; KOG1535; Eukaryota.
DR HOGENOM; CLU_028458_5_0_1; -.
DR InParanoid; Q10B63; -.
DR OMA; YALSIDM; -.
DR OrthoDB; 1216556at2759; -.
DR PlantReactome; R-OSA-1119506; tyrosine degradation I.
DR Proteomes; UP000000763; Chromosome 3.
DR Proteomes; UP000007752; Chromosome 3.
DR Proteomes; UP000059680; Chromosome 3.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0018773; F:acetylpyruvate hydrolase activity; IBA:GO_Central.
DR GO; GO:0047621; F:acylpyruvate hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.90.850.10; -; 1.
DR InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR Pfam; PF01557; FAA_hydrolase; 1.
DR SUPFAM; SSF56529; SSF56529; 1.
PE 3: Inferred from homology;
KW Hydrolase; Metal-binding; Mitochondrion; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..30
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 31..226
FT /note="Probable acylpyruvase FAHD2, mitochondrial"
FT /id="PRO_0000442053"
FT BINDING 69
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000250|UniProtKB:Q6P587"
FT BINDING 71
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000250|UniProtKB:Q6P587"
FT BINDING 100
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000250|UniProtKB:Q6P587"
SQ SEQUENCE 226 AA; 24071 MW; 36D6FD515CDF4C03 CRC64;
MAAAAQRLLA ASTKIVGVGR NFVAHAKELG NPVPKEPVLF LKPTSSFLHA GVAGAAIEVP
EPVESLHHEV ELAVVISQRA RDVPEASAMD FVGGYALALD MTARELQSAA KSAGLPWTLG
KAQDTFTPIS AVIPKSDVAN PDDLELWLKV DDELRQKGST SDMIFKIPSL ISYISSIMTL
MEGDVILTGT PEGVGPVRPG QKIKAGITGL IDVEFDVQKR KRSFST
