ID   FAHD2_RAT               Reviewed;         313 AA.
AC   B2RYW9;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Fumarylacetoacetate hydrolase domain-containing protein 2;
DE            EC=3.-.-.-;
GN   Name=Fahd2; Synonyms=Fahd2a;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pituitary anterior lobe;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RA   Maurya D.K., Bhargava P.;
RL   Submitted (MAR-2009) to UniProtKB.
CC   -!- FUNCTION: May have hydrolase activity. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000305};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000305};
CC   -!- SIMILARITY: Belongs to the FAH family. {ECO:0000305}.
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DR   EMBL; BC166933; AAI66933.1; -; mRNA.
DR   RefSeq; NP_001128306.1; NM_001134834.1.
DR   AlphaFoldDB; B2RYW9; -.
DR   SMR; B2RYW9; -.
DR   STRING; 10116.ENSRNOP00000018922; -.
DR   iPTMnet; B2RYW9; -.
DR   PhosphoSitePlus; B2RYW9; -.
DR   jPOST; B2RYW9; -.
DR   PaxDb; B2RYW9; -.
DR   PeptideAtlas; B2RYW9; -.
DR   PRIDE; B2RYW9; -.
DR   GeneID; 296131; -.
DR   KEGG; rno:296131; -.
DR   UCSC; RGD:1563674; rat.
DR   CTD; 51011; -.
DR   RGD; 1563674; Fahd2a.
DR   VEuPathDB; HostDB:ENSRNOG00000013974; -.
DR   eggNOG; KOG1535; Eukaryota.
DR   HOGENOM; CLU_028458_3_2_1; -.
DR   InParanoid; B2RYW9; -.
DR   OMA; PPEPIIF; -.
DR   OrthoDB; 1216556at2759; -.
DR   PhylomeDB; B2RYW9; -.
DR   TreeFam; TF300911; -.
DR   PRO; PR:B2RYW9; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000013974; Expressed in kidney and 20 other tissues.
DR   Genevisible; B2RYW9; RN.
DR   GO; GO:0016836; F:hydro-lyase activity; IBA:GO_Central.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.850.10; -; 1.
DR   InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR   InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR   Pfam; PF01557; FAA_hydrolase; 1.
DR   SUPFAM; SSF56529; SSF56529; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Calcium; Hydrolase; Magnesium; Metal-binding;
KW   Reference proteome.
FT   CHAIN           1..313
FT                   /note="Fumarylacetoacetate hydrolase domain-containing
FT                   protein 2"
FT                   /id="PRO_0000367321"
FT   BINDING         159
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P587"
FT   BINDING         161
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P587"
FT   BINDING         190
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P587"
FT   MOD_RES         202
FT                   /note="N6-acetyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q3TC72"
FT   MOD_RES         202
FT                   /note="N6-succinyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q3TC72"
FT   MOD_RES         233
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3TC72"
SQ   SEQUENCE   313 AA;  34581 MW;  116A79EE852633E0 CRC64;
     MLGSGRRRLL STLLQVQKRP CQPCRNMRLV QFQAPHLEEP HVGLESGIGG GVVDLNTFDP
     ALPKTMVQFL ERGETALSVA RRALAAQLPL IPRSQVTFLA PVTRPDKVIC VGLNYADHCQ
     EQNVRVPKNP IIFSKFSSSI VGPYDSIILP PESKEVDWEV EMAVVIGKKG KHIKATDVMA
     YVAGFTVAHD VSARDWQMRN GKQWLLGKTF DTFCPLGPAL VTKDTIADPH NLKISCRVNG
     EIVQSSNTNQ MVFKTEDLIA WVSQFVTLYP GDILLTGTPP GVGMFRKPPV FLKKGDEVQC
     EIEELGVIIN KVV