ID   FAHD2_XENLA             Reviewed;         319 AA.
AC   Q6GLT8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Fumarylacetoacetate hydrolase domain-containing protein 2;
DE            EC=3.-.-.-;
GN   Name=fahd2; Synonyms=fahd2a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May have hydrolase activity. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000305};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000305};
CC   -!- SIMILARITY: Belongs to the FAH family. {ECO:0000305}.
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DR   EMBL; BC074365; AAH74365.1; -; mRNA.
DR   RefSeq; NP_001086239.1; NM_001092770.1.
DR   AlphaFoldDB; Q6GLT8; -.
DR   SMR; Q6GLT8; -.
DR   MaxQB; Q6GLT8; -.
DR   DNASU; 444668; -.
DR   GeneID; 444668; -.
DR   KEGG; xla:444668; -.
DR   CTD; 444668; -.
DR   Xenbase; XB-GENE-964035; fahd2a.L.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 444668; Expressed in testis and 19 other tissues.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.850.10; -; 1.
DR   InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR   InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR   Pfam; PF01557; FAA_hydrolase; 1.
DR   SUPFAM; SSF56529; SSF56529; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Hydrolase; Magnesium; Metal-binding; Reference proteome.
FT   CHAIN           1..319
FT                   /note="Fumarylacetoacetate hydrolase domain-containing
FT                   protein 2"
FT                   /id="PRO_0000367322"
FT   BINDING         164
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P587"
FT   BINDING         166
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P587"
FT   BINDING         195
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P587"
SQ   SEQUENCE   319 AA;  35122 MW;  9FADF502FD1CD17A CRC64;
     MLTQTRVALR VLKNAHLTLP KRNISQSPAL SMRLVQFQSS DSPSPRIGLE LQDGGNIIDL
     NAYDPSLPCR MREFLEMGES ALQTAKSALD SNQHILSRSN ISLLAPITNP EKIICIGMNY
     VDHCLEQNVP VPKEPIIFNK FASSIVGPSD PIRIPEESQE VDWEAELAFV IGKKGKNIKE
     EDAMDHVVGY TVAHDVSARD WQMKKNGKQW LLGKTFDTFC PLGPALVTKD VISDPHNLGI
     RCRVNGDLVQ NSNTNQMVFK TEALIAWASK FVTLNPGDVF LTGTPPGVGV FRKPPVFLKA
     GDVVRCEIDE LGAISNPVV