FAIM1_MOUSE
ID FAIM1_MOUSE Reviewed; 179 AA.
AC Q9WUD8; Q9DAK6;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Fas apoptotic inhibitory molecule 1;
GN Name=Faim; Synonyms=Faim1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Thymus;
RX PubMed=10075978; DOI=10.1084/jem.189.6.949;
RA Schneider T.J., Fischer G.M., Donohoe T.J., Colarusso T.P., Rothstein T.L.;
RT "A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM)
RT isolated from inducibly Fas-resistant B lymphocytes.";
RL J. Exp. Med. 189:949-956(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP STRUCTURE BY NMR OF 91-179, AND SUBCELLULAR LOCATION.
RX PubMed=19168072; DOI=10.1016/j.jmb.2009.01.004;
RA Hemond M., Rothstein T.L., Wagner G.;
RT "Fas apoptosis inhibitory molecule contains a novel beta-sandwich in
RT contact with a partially ordered domain.";
RL J. Mol. Biol. 386:1024-1037(2009).
CC -!- FUNCTION: Plays a role as an inducible effector molecule that mediates
CC Fas resistance produced by surface Ig engagement in B cells.
CC {ECO:0000269|PubMed:10075978}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19168072}.
CC -!- TISSUE SPECIFICITY: Widely expressed, with the highest levels in brain,
CC thymus, kidney, and spleen. {ECO:0000269|PubMed:10075978}.
CC -!- SIMILARITY: Belongs to the FAIM1 family. {ECO:0000305}.
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DR EMBL; AF130367; AAD23879.1; -; mRNA.
DR EMBL; AK005762; BAB24225.1; -; mRNA.
DR EMBL; BC079662; AAH79662.1; -; mRNA.
DR CCDS; CCDS23431.1; -.
DR RefSeq; NP_001116323.1; NM_001122851.1.
DR RefSeq; NP_035940.3; NM_011810.3.
DR PDB; 2KD2; NMR; -; A=91-179.
DR PDBsum; 2KD2; -.
DR AlphaFoldDB; Q9WUD8; -.
DR BMRB; Q9WUD8; -.
DR SMR; Q9WUD8; -.
DR STRING; 10090.ENSMUSP00000108532; -.
DR PhosphoSitePlus; Q9WUD8; -.
DR EPD; Q9WUD8; -.
DR jPOST; Q9WUD8; -.
DR MaxQB; Q9WUD8; -.
DR PaxDb; Q9WUD8; -.
DR PRIDE; Q9WUD8; -.
DR ProteomicsDB; 271721; -.
DR Ensembl; ENSMUST00000035038; ENSMUSP00000035038; ENSMUSG00000032463.
DR GeneID; 23873; -.
DR KEGG; mmu:23873; -.
DR UCSC; uc009rdt.2; mouse.
DR CTD; 55179; -.
DR MGI; MGI:1344387; Faim.
DR VEuPathDB; HostDB:ENSMUSG00000032463; -.
DR eggNOG; KOG4352; Eukaryota.
DR GeneTree; ENSGT00390000007364; -.
DR InParanoid; Q9WUD8; -.
DR OMA; PQEYRIM; -.
DR OrthoDB; 1301275at2759; -.
DR PhylomeDB; Q9WUD8; -.
DR BioGRID-ORCS; 23873; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Faim; mouse.
DR EvolutionaryTrace; Q9WUD8; -.
DR PRO; PR:Q9WUD8; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9WUD8; protein.
DR Bgee; ENSMUSG00000032463; Expressed in retinal neural layer and 246 other tissues.
DR ExpressionAtlas; Q9WUD8; baseline and differential.
DR Genevisible; Q9WUD8; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; ISO:MGI.
DR GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IDA:MGI.
DR GO; GO:0050769; P:positive regulation of neurogenesis; ISO:MGI.
DR Gene3D; 2.40.128.180; -; 2.
DR InterPro; IPR010695; FAIM1.
DR InterPro; IPR038513; FAIM1_dom_sf.
DR PANTHER; PTHR13088; PTHR13088; 1.
DR Pfam; PF06905; FAIM1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Apoptosis; Cytoplasm; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9NVQ4"
FT CHAIN 2..179
FT /note="Fas apoptotic inhibitory molecule 1"
FT /id="PRO_0000087174"
FT MOD_RES 2
FT /note="N-acetylthreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9NVQ4"
FT CONFLICT 157
FT /note="G -> R (in Ref. 2; BAB24225)"
FT /evidence="ECO:0000305"
FT STRAND 97..104
FT /evidence="ECO:0007829|PDB:2KD2"
FT STRAND 107..114
FT /evidence="ECO:0007829|PDB:2KD2"
FT TURN 115..118
FT /evidence="ECO:0007829|PDB:2KD2"
FT STRAND 119..126
FT /evidence="ECO:0007829|PDB:2KD2"
FT STRAND 135..144
FT /evidence="ECO:0007829|PDB:2KD2"
FT STRAND 147..171
FT /evidence="ECO:0007829|PDB:2KD2"
SQ SEQUENCE 179 AA; 20201 MW; 10E49A8E65926556 CRC64;
MTDLVAVWDV ALSDGVHKIE FEHGTTSGKR VVYVDGKEEI RREWMFKLVG KETFFVGAAK
TKATINIDAI SGFAYEYTLE IDGKSLKKYM ENRSKTTSTW VLRLDGEDLR VVLEKDTMDV
WCNGQKMETA GEFVDDGTET HFSVGNHGCY IKAVSSGKRK EGIIHTLIVD NREIPELTQ
