FAIM1_RAT
ID FAIM1_RAT Reviewed; 201 AA.
AC Q8R5H8; Q8VHR4;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Fas apoptotic inhibitory molecule 1;
DE Short=rFAIM;
GN Name=Faim; Synonyms=Faim1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=Sprague-Dawley; TISSUE=Heart;
RA Sole C., Yuste V.J., Bayascas J.R., Espinet C., Comella J.X.;
RT "Cloning and characterization of rat Fas-apoptosis inhibitory molecule
RT (rFAIM).";
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role as an inducible effector molecule that mediates
CC Fas resistance produced by surface Ig engagement in B cells.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=Long, FAIM-L;
CC IsoId=Q8R5H8-1; Sequence=Displayed;
CC Name=2; Synonyms=Short, FAIM-S;
CC IsoId=Q8R5H8-2; Sequence=VSP_008993;
CC -!- SIMILARITY: Belongs to the FAIM1 family. {ECO:0000305}.
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DR EMBL; AF412334; AAL60162.1; -; mRNA.
DR EMBL; AF467453; AAL77007.1; -; mRNA.
DR RefSeq; NP_543171.1; NM_080895.1. [Q8R5H8-2]
DR RefSeq; XP_002730005.1; XM_002729959.4. [Q8R5H8-1]
DR RefSeq; XP_006243673.1; XM_006243611.3. [Q8R5H8-1]
DR RefSeq; XP_006243675.1; XM_006243613.2. [Q8R5H8-2]
DR RefSeq; XP_006243676.1; XM_006243614.3. [Q8R5H8-2]
DR RefSeq; XP_006243678.1; XM_006243616.3. [Q8R5H8-1]
DR RefSeq; XP_006243679.1; XM_006243617.3. [Q8R5H8-1]
DR RefSeq; XP_006243681.1; XM_006243619.3. [Q8R5H8-2]
DR RefSeq; XP_017450913.1; XM_017595424.1. [Q8R5H8-2]
DR RefSeq; XP_017451611.1; XM_017596122.1. [Q8R5H8-2]
DR AlphaFoldDB; Q8R5H8; -.
DR SMR; Q8R5H8; -.
DR BioGRID; 250864; 1.
DR STRING; 10116.ENSRNOP00000039749; -.
DR jPOST; Q8R5H8; -.
DR PaxDb; Q8R5H8; -.
DR Ensembl; ENSRNOT00000045821; ENSRNOP00000039749; ENSRNOG00000030069. [Q8R5H8-1]
DR Ensembl; ENSRNOT00000047613; ENSRNOP00000049149; ENSRNOG00000030069. [Q8R5H8-2]
DR GeneID; 140930; -.
DR KEGG; rno:140930; -.
DR UCSC; RGD:620572; rat. [Q8R5H8-1]
DR CTD; 55179; -.
DR RGD; 620572; Faim.
DR VEuPathDB; HostDB:ENSRNOG00000048802; -.
DR eggNOG; KOG4352; Eukaryota.
DR GeneTree; ENSGT00390000007364; -.
DR HOGENOM; CLU_109086_0_0_1; -.
DR InParanoid; Q8R5H8; -.
DR OMA; PQEYRIM; -.
DR OrthoDB; 1301275at2759; -.
DR PhylomeDB; Q8R5H8; -.
DR TreeFam; TF314971; -.
DR PRO; PR:Q8R5H8; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000030069; Expressed in thymus and 16 other tissues.
DR Genevisible; Q8R5H8; RN.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IMP:RGD.
DR GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; ISO:RGD.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IMP:RGD.
DR Gene3D; 2.40.128.180; -; 2.
DR InterPro; IPR010695; FAIM1.
DR InterPro; IPR038513; FAIM1_dom_sf.
DR PANTHER; PTHR13088; PTHR13088; 1.
DR Pfam; PF06905; FAIM1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Apoptosis; Cytoplasm; Reference proteome.
FT CHAIN 1..201
FT /note="Fas apoptotic inhibitory molecule 1"
FT /id="PRO_0000087175"
FT VAR_SEQ 1..22
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_008993"
SQ SEQUENCE 201 AA; 22705 MW; 36AED1F0CB60E3C3 CRC64;
MASGDDSPIF EDDESPLCSL EKMTDLVAVW DVALSDGVHK IEFEHGTTSG KRVVYVDGKE
EIRREWMFKL VGKETFFVGA AKTKATINID AISGFAYEYT LEIDGKSLKK YMENRSKTTN
TWVLHLDGEE LRVVLEKDTM DVWCNGQRME TAGEFVDDGT ETHFSVGNHD CYIKAVSSGK
RREGIIHTLI VDNREIPELT Q