ID   FAIM1_RAT               Reviewed;         201 AA.
AC   Q8R5H8; Q8VHR4;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Fas apoptotic inhibitory molecule 1;
DE            Short=rFAIM;
GN   Name=Faim; Synonyms=Faim1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=Sprague-Dawley; TISSUE=Heart;
RA   Sole C., Yuste V.J., Bayascas J.R., Espinet C., Comella J.X.;
RT   "Cloning and characterization of rat Fas-apoptosis inhibitory molecule
RT   (rFAIM).";
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role as an inducible effector molecule that mediates
CC       Fas resistance produced by surface Ig engagement in B cells.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=Long, FAIM-L;
CC         IsoId=Q8R5H8-1; Sequence=Displayed;
CC       Name=2; Synonyms=Short, FAIM-S;
CC         IsoId=Q8R5H8-2; Sequence=VSP_008993;
CC   -!- SIMILARITY: Belongs to the FAIM1 family. {ECO:0000305}.
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DR   EMBL; AF412334; AAL60162.1; -; mRNA.
DR   EMBL; AF467453; AAL77007.1; -; mRNA.
DR   RefSeq; NP_543171.1; NM_080895.1. [Q8R5H8-2]
DR   RefSeq; XP_002730005.1; XM_002729959.4. [Q8R5H8-1]
DR   RefSeq; XP_006243673.1; XM_006243611.3. [Q8R5H8-1]
DR   RefSeq; XP_006243675.1; XM_006243613.2. [Q8R5H8-2]
DR   RefSeq; XP_006243676.1; XM_006243614.3. [Q8R5H8-2]
DR   RefSeq; XP_006243678.1; XM_006243616.3. [Q8R5H8-1]
DR   RefSeq; XP_006243679.1; XM_006243617.3. [Q8R5H8-1]
DR   RefSeq; XP_006243681.1; XM_006243619.3. [Q8R5H8-2]
DR   RefSeq; XP_017450913.1; XM_017595424.1. [Q8R5H8-2]
DR   RefSeq; XP_017451611.1; XM_017596122.1. [Q8R5H8-2]
DR   AlphaFoldDB; Q8R5H8; -.
DR   SMR; Q8R5H8; -.
DR   BioGRID; 250864; 1.
DR   STRING; 10116.ENSRNOP00000039749; -.
DR   jPOST; Q8R5H8; -.
DR   PaxDb; Q8R5H8; -.
DR   Ensembl; ENSRNOT00000045821; ENSRNOP00000039749; ENSRNOG00000030069. [Q8R5H8-1]
DR   Ensembl; ENSRNOT00000047613; ENSRNOP00000049149; ENSRNOG00000030069. [Q8R5H8-2]
DR   GeneID; 140930; -.
DR   KEGG; rno:140930; -.
DR   UCSC; RGD:620572; rat. [Q8R5H8-1]
DR   CTD; 55179; -.
DR   RGD; 620572; Faim.
DR   VEuPathDB; HostDB:ENSRNOG00000048802; -.
DR   eggNOG; KOG4352; Eukaryota.
DR   GeneTree; ENSGT00390000007364; -.
DR   HOGENOM; CLU_109086_0_0_1; -.
DR   InParanoid; Q8R5H8; -.
DR   OMA; PQEYRIM; -.
DR   OrthoDB; 1301275at2759; -.
DR   PhylomeDB; Q8R5H8; -.
DR   TreeFam; TF314971; -.
DR   PRO; PR:Q8R5H8; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000030069; Expressed in thymus and 16 other tissues.
DR   Genevisible; Q8R5H8; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IMP:RGD.
DR   GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; ISO:RGD.
DR   GO; GO:0050769; P:positive regulation of neurogenesis; IMP:RGD.
DR   Gene3D; 2.40.128.180; -; 2.
DR   InterPro; IPR010695; FAIM1.
DR   InterPro; IPR038513; FAIM1_dom_sf.
DR   PANTHER; PTHR13088; PTHR13088; 1.
DR   Pfam; PF06905; FAIM1; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Apoptosis; Cytoplasm; Reference proteome.
FT   CHAIN           1..201
FT                   /note="Fas apoptotic inhibitory molecule 1"
FT                   /id="PRO_0000087175"
FT   VAR_SEQ         1..22
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_008993"
SQ   SEQUENCE   201 AA;  22705 MW;  36AED1F0CB60E3C3 CRC64;
     MASGDDSPIF EDDESPLCSL EKMTDLVAVW DVALSDGVHK IEFEHGTTSG KRVVYVDGKE
     EIRREWMFKL VGKETFFVGA AKTKATINID AISGFAYEYT LEIDGKSLKK YMENRSKTTN
     TWVLHLDGEE LRVVLEKDTM DVWCNGQRME TAGEFVDDGT ETHFSVGNHD CYIKAVSSGK
     RREGIIHTLI VDNREIPELT Q