FAKD3_BOVIN
ID FAKD3_BOVIN Reviewed; 660 AA.
AC Q58CX2;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=FAST kinase domain-containing protein 3, mitochondrial;
DE Flags: Precursor;
GN Name=FASTKD3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 482-660 (ISOFORM 1).
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for normal mitochondrial respiration. Increases
CC steady-state levels and half-lives of a subset of mature mitochondrial
CC mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1
CC mRNA translation and increases mitochondrial complex IV assembly and
CC activity. {ECO:0000250|UniProtKB:Q14CZ7}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q14CZ7}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q58CX2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q58CX2-2; Sequence=VSP_024622, VSP_024623;
CC -!- DOMAIN: RAP domain is required for FASTKD3 function in mRNA stability
CC and translation. {ECO:0000250|UniProtKB:Q14CZ7}.
CC -!- SIMILARITY: Belongs to the FAST kinase family. {ECO:0000305}.
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DR EMBL; BT021825; AAX46672.1; -; mRNA.
DR EMBL; DT840127; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001019699.2; NM_001024528.2. [Q58CX2-1]
DR RefSeq; XP_005221703.1; XM_005221646.3. [Q58CX2-1]
DR AlphaFoldDB; Q58CX2; -.
DR SMR; Q58CX2; -.
DR STRING; 9913.ENSBTAP00000043394; -.
DR PaxDb; Q58CX2; -.
DR PRIDE; Q58CX2; -.
DR Ensembl; ENSBTAT00000046066; ENSBTAP00000043394; ENSBTAG00000009400. [Q58CX2-1]
DR GeneID; 513260; -.
DR KEGG; bta:513260; -.
DR CTD; 79072; -.
DR VEuPathDB; HostDB:ENSBTAG00000009400; -.
DR eggNOG; ENOG502QW8P; Eukaryota.
DR GeneTree; ENSGT01030000234607; -.
DR HOGENOM; CLU_028858_0_0_1; -.
DR InParanoid; Q58CX2; -.
DR OMA; VQIPYHE; -.
DR OrthoDB; 352329at2759; -.
DR TreeFam; TF324885; -.
DR Proteomes; UP000009136; Chromosome 20.
DR Bgee; ENSBTAG00000009400; Expressed in oocyte and 105 other tissues.
DR GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0035770; C:ribonucleoprotein granule; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; ISS:UniProtKB.
DR GO; GO:0000963; P:mitochondrial RNA processing; IBA:GO_Central.
DR GO; GO:0070131; P:positive regulation of mitochondrial translation; ISS:UniProtKB.
DR GO; GO:0044528; P:regulation of mitochondrial mRNA stability; ISS:UniProtKB.
DR InterPro; IPR013579; FAST_2.
DR InterPro; IPR010622; FAST_Leu-rich.
DR InterPro; IPR013584; RAP.
DR Pfam; PF06743; FAST_1; 1.
DR Pfam; PF08368; FAST_2; 1.
DR Pfam; PF08373; RAP; 1.
DR SMART; SM00952; RAP; 1.
DR PROSITE; PS51286; RAP; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..57
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 58..660
FT /note="FAST kinase domain-containing protein 3,
FT mitochondrial"
FT /id="PRO_0000284714"
FT DOMAIN 591..649
FT /note="RAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00619"
FT VAR_SEQ 453..559
FT /note="HSCSLIESHPVNFMAKIFSPYFLQQLQGAESYLDRLSLAQLTQLFLTSILEC
FT PFYKGPKLLPKFQVKSFLTPCSSLETPMDFHLYKSVMIGLIDLLGARLYFSSKVL ->
FT LLPSIFPSIKIFSSEPVLRIKWPKYWSFSISPSHEYSRWIFLEDGLVGSPCSPRDSQEP
FT SPTPQFESINSSVLSSLYSPTVTSRHDYWKNHSFDSMDLCQQGDVFAF (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:16305752"
FT /id="VSP_024622"
FT VAR_SEQ 560..660
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16305752"
FT /id="VSP_024623"
FT CONFLICT 45
FT /note="F -> L (in Ref. 1; AAX46672)"
FT /evidence="ECO:0000305"
FT CONFLICT 343
FT /note="Y -> F (in Ref. 1; AAX46672)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 660 AA; 75487 MW; 96B35740D3EB4706 CRC64;
MALVTLRRNL YHLSDFRIHG ALAALKTQQV NHVHKTVKEH LCPWFWSQHP GPIRVRFHHA
HCKKFHSENG NDLHPVGEPG FSQVHNWDRF EHSVKNVDEQ MFYRKLNSFT SSGEILRFVS
TLETLPDTMM AGALHRICEV ERKDGDQRLP KEILESSAFQ ALCDRFGRDP SDLSNAGLVT
AFQALTLLCG DPQSHLLMNL EAECQHRLER GGLDVHSLCI LGETLIKLHG PGCSTLDLII
YQLQGESLET FTPEDIVTVY RLLQASPEKA DQQQRFLNKI NHFSLSLVSN LSPKLMSQML
TALVVLDQTQ ALPLVIKLSK YVVRHIARFT SEELRKVLEA LIYFGHSDRF FTETLEQHVA
SLCLTLDPEL VSRVMEYCSR KLILSEPIFN AVAETFVCQA EKFSPSQTAK LIEPFGKLNY
LPPNASALFR KLENMLLTRF NHFPPKTLLR LLHSCSLIES HPVNFMAKIF SPYFLQQLQG
AESYLDRLSL AQLTQLFLTS ILECPFYKGP KLLPKFQVKS FLTPCSSLET PMDFHLYKSV
MIGLIDLLGA RLYFSSKVLT PYCYTIDVEI KLDEDGFVLP FTIDEDVHKR VALCIDGPKR
FCLNSKHLLG KEATKQRHLR LLGYQVVQIP YYEIEMLKSR LELVDYLQGK LFSQNSGGHW
