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FAKD3_MOUSE
ID   FAKD3_MOUSE             Reviewed;         661 AA.
AC   Q8BSN9; Q5XKD3; Q6P9N4; Q8CB52; Q8CCG7;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=FAST kinase domain-containing protein 3, mitochondrial;
DE   Flags: Precursor;
GN   Name=Fastkd3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J; TISSUE=Forelimb, Testis, and Vagina;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC   STRAIN=C57BL/6J; TISSUE=Brain, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=20869947; DOI=10.1016/j.bbrc.2010.09.075;
RA   Simarro M., Gimenez-Cassina A., Kedersha N., Lazaro J.B., Adelmant G.O.,
RA   Marto J.A., Rhee K., Tisdale S., Danial N., Benarafa C., Orduna A.,
RA   Anderson P.;
RT   "Fast kinase domain-containing protein 3 is a mitochondrial protein
RT   essential for cellular respiration.";
RL   Biochem. Biophys. Res. Commun. 401:440-446(2010).
CC   -!- FUNCTION: Required for normal mitochondrial respiration. Increases
CC       steady-state levels and half-lives of a subset of mature mitochondrial
CC       mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1
CC       mRNA translation and increases mitochondrial complex IV assembly and
CC       activity. {ECO:0000250|UniProtKB:Q14CZ7}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q14CZ7}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q8BSN9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8BSN9-2; Sequence=VSP_024625, VSP_024626;
CC       Name=3;
CC         IsoId=Q8BSN9-3; Sequence=VSP_024624;
CC   -!- TISSUE SPECIFICITY: Expression detected in spleen, testis, colon,
CC       heart, smooth muscle, kidney, brain, lung, liver, brown and white
CC       adipose tissue with highest expression in testis and smooth muscle.
CC       {ECO:0000269|PubMed:20869947}.
CC   -!- DOMAIN: RAP domain is required for FASTKD3 function in mRNA stability
CC       and translation. {ECO:0000250|UniProtKB:Q14CZ7}.
CC   -!- SIMILARITY: Belongs to the FAST kinase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC27277.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AK031142; BAC27277.1; ALT_FRAME; mRNA.
DR   EMBL; AK033189; BAC28191.1; -; mRNA.
DR   EMBL; AK036778; BAC29573.1; -; mRNA.
DR   EMBL; BC042506; AAH42506.1; -; mRNA.
DR   EMBL; BC060688; AAH60688.1; -; mRNA.
DR   CCDS; CCDS36719.1; -. [Q8BSN9-1]
DR   RefSeq; NP_001317352.1; NM_001330423.1. [Q8BSN9-1]
DR   RefSeq; NP_081399.3; NM_027123.5. [Q8BSN9-1]
DR   AlphaFoldDB; Q8BSN9; -.
DR   SMR; Q8BSN9; -.
DR   STRING; 10090.ENSMUSP00000061737; -.
DR   iPTMnet; Q8BSN9; -.
DR   PhosphoSitePlus; Q8BSN9; -.
DR   EPD; Q8BSN9; -.
DR   PaxDb; Q8BSN9; -.
DR   PeptideAtlas; Q8BSN9; -.
DR   PRIDE; Q8BSN9; -.
DR   ProteomicsDB; 271858; -. [Q8BSN9-1]
DR   ProteomicsDB; 271859; -. [Q8BSN9-2]
DR   ProteomicsDB; 271860; -. [Q8BSN9-3]
DR   Antibodypedia; 22426; 190 antibodies from 28 providers.
DR   DNASU; 69577; -.
DR   Ensembl; ENSMUST00000051784; ENSMUSP00000061737; ENSMUSG00000021532. [Q8BSN9-1]
DR   Ensembl; ENSMUST00000223319; ENSMUSP00000152635; ENSMUSG00000021532. [Q8BSN9-2]
DR   GeneID; 69577; -.
DR   KEGG; mmu:69577; -.
DR   UCSC; uc007rca.1; mouse. [Q8BSN9-1]
DR   CTD; 79072; -.
DR   MGI; MGI:1916827; Fastkd3.
DR   VEuPathDB; HostDB:ENSMUSG00000021532; -.
DR   eggNOG; ENOG502QW8P; Eukaryota.
DR   GeneTree; ENSGT01030000234607; -.
DR   HOGENOM; CLU_028858_0_0_1; -.
DR   InParanoid; Q8BSN9; -.
DR   OMA; VQIPYHE; -.
DR   OrthoDB; 352329at2759; -.
DR   PhylomeDB; Q8BSN9; -.
DR   TreeFam; TF324885; -.
DR   BioGRID-ORCS; 69577; 5 hits in 74 CRISPR screens.
DR   ChiTaRS; Fastkd3; mouse.
DR   PRO; PR:Q8BSN9; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   RNAct; Q8BSN9; protein.
DR   Bgee; ENSMUSG00000021532; Expressed in cleaving embryo and 209 other tissues.
DR   ExpressionAtlas; Q8BSN9; baseline and differential.
DR   Genevisible; Q8BSN9; MM.
DR   GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0035770; C:ribonucleoprotein granule; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; ISS:UniProtKB.
DR   GO; GO:0000963; P:mitochondrial RNA processing; IBA:GO_Central.
DR   GO; GO:0070131; P:positive regulation of mitochondrial translation; ISS:UniProtKB.
DR   GO; GO:0044528; P:regulation of mitochondrial mRNA stability; ISS:UniProtKB.
DR   InterPro; IPR013579; FAST_2.
DR   InterPro; IPR010622; FAST_Leu-rich.
DR   InterPro; IPR013584; RAP.
DR   Pfam; PF06743; FAST_1; 1.
DR   Pfam; PF08368; FAST_2; 1.
DR   Pfam; PF08373; RAP; 1.
DR   SMART; SM00952; RAP; 1.
DR   PROSITE; PS51286; RAP; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000305"
FT   CHAIN           ?..661
FT                   /note="FAST kinase domain-containing protein 3,
FT                   mitochondrial"
FT                   /id="PRO_0000284716"
FT   DOMAIN          592..650
FT                   /note="RAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00619"
FT   VAR_SEQ         510..661
FT                   /note="GPKLLPKYQVKSFLTPCCSLETPLDLHLYKSVVIGLIDLLGSRLYFASKVLT
FT                   PYYYTIDVEVKLDEDGFVLPCTVDEDIHKRVALCIDGPQRFCLDSKHLLGKEATKQRHL
FT                   RLLGYQVVQLPYHELELLTSRLELVDYLQRKLFSQSSAVHW -> VRTETRVV (in
FT                   isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_024624"
FT   VAR_SEQ         568..571
FT                   /note="DVEV -> ASAL (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:16141072"
FT                   /id="VSP_024625"
FT   VAR_SEQ         572..661
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:16141072"
FT                   /id="VSP_024626"
FT   CONFLICT        34
FT                   /note="P -> Q (in Ref. 2; AAH42506)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        108
FT                   /note="Y -> V (in Ref. 2; AAH42506)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        175
FT                   /note="N -> S (in Ref. 2; AAH42506)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        258
FT                   /note="T -> A (in Ref. 2; AAH42506)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        266
FT                   /note="V -> A (in Ref. 2; AAH42506)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        276
FT                   /note="M -> T (in Ref. 2; AAH42506)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        533
FT                   /note="L -> M (in Ref. 2; AAH42506)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   661 AA;  75317 MW;  67A53D7BFD52AB74 CRC64;
     MAFITLRRAF CHKSILWIPG AVVALKIHPA SHAPKAVTDR LSVCFCSLQP ELFRVRFHHA
     YCKNFHSEKG NDFHPVGEPW SSQAQEWNQP GQSLQNEDEE MLFRRLSYFT SFEEVLSFIS
     ALDTLPVPLA MAALLRICEI GRRDGEQRLP EGVLENRAFQ ALCLRCERDP SHLTNAGLVT
     ALQSLLTLLP ADPQSSLMLS LVAECQRRLQ RGNLEVHHLC VLGESLAMLQ GASCETLKLV
     VRQLQSKSVE TFAPEEITSV YRILQVCPEE VDKHQMFLNT LNNFSISVVP YLSPKSISHV
     LTALVALDQT HALPLLIKLG KYVVRYIPRF TNEELRKVLE AFVYFGHSDR FFTEALEQHV
     SALCFSLDPA VASSVMGYCS RKRILSKPIF DVVSEIVVCQ WDRLSPSQIA ELIEPFGKLN
     YVPPNAPALF RKVENVLCAR LHHFPPKMLL RLLHSCALIE RHPVNFMSKL FSPFFLQRLQ
     GKESYLDRLS LAQLTQLFLT SVLECPFYKG PKLLPKYQVK SFLTPCCSLE TPLDLHLYKS
     VVIGLIDLLG SRLYFASKVL TPYYYTIDVE VKLDEDGFVL PCTVDEDIHK RVALCIDGPQ
     RFCLDSKHLL GKEATKQRHL RLLGYQVVQL PYHELELLTS RLELVDYLQR KLFSQSSAVH
     W
 
 
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