ID   FAKD3_RAT               Reviewed;         656 AA.
AC   Q68FN9;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=FAST kinase domain-containing protein 3, mitochondrial;
DE   Flags: Precursor;
GN   Name=Fastkd3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 66-656.
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Required for normal mitochondrial respiration. Increases
CC       steady-state levels and half-lives of a subset of mature mitochondrial
CC       mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1
CC       mRNA translation and increases mitochondrial complex IV assembly and
CC       activity. {ECO:0000250|UniProtKB:Q14CZ7}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q14CZ7}.
CC   -!- DOMAIN: RAP domain is required for FASTKD3 function in mRNA stability
CC       and translation. {ECO:0000250|UniProtKB:Q14CZ7}.
CC   -!- SIMILARITY: Belongs to the FAST kinase family. {ECO:0000305}.
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DR   EMBL; AABR03104692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC079475; AAH79475.1; -; mRNA.
DR   RefSeq; NP_001076043.1; NM_001082574.1.
DR   RefSeq; XP_006227871.1; XM_006227809.2.
DR   RefSeq; XP_006227873.1; XM_006227811.2.
DR   RefSeq; XP_017444338.1; XM_017588849.1.
DR   AlphaFoldDB; Q68FN9; -.
DR   SMR; Q68FN9; -.
DR   STRING; 10116.ENSRNOP00000029498; -.
DR   PhosphoSitePlus; Q68FN9; -.
DR   PaxDb; Q68FN9; -.
DR   Ensembl; ENSRNOT00000034410; ENSRNOP00000029498; ENSRNOG00000027422.
DR   GeneID; 290946; -.
DR   KEGG; rno:290946; -.
DR   UCSC; RGD:1309729; rat.
DR   CTD; 79072; -.
DR   RGD; 1309729; Fastkd3.
DR   eggNOG; ENOG502QW8P; Eukaryota.
DR   GeneTree; ENSGT01030000234607; -.
DR   HOGENOM; CLU_028858_0_0_1; -.
DR   InParanoid; Q68FN9; -.
DR   OMA; VQIPYHE; -.
DR   OrthoDB; 352329at2759; -.
DR   PhylomeDB; Q68FN9; -.
DR   TreeFam; TF324885; -.
DR   PRO; PR:Q68FN9; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000027422; Expressed in ovary and 19 other tissues.
DR   ExpressionAtlas; Q68FN9; baseline and differential.
DR   Genevisible; Q68FN9; RN.
DR   GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0035770; C:ribonucleoprotein granule; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; ISS:UniProtKB.
DR   GO; GO:0000963; P:mitochondrial RNA processing; IBA:GO_Central.
DR   GO; GO:0070131; P:positive regulation of mitochondrial translation; ISS:UniProtKB.
DR   GO; GO:0044528; P:regulation of mitochondrial mRNA stability; ISS:UniProtKB.
DR   InterPro; IPR013579; FAST_2.
DR   InterPro; IPR010622; FAST_Leu-rich.
DR   InterPro; IPR013584; RAP.
DR   Pfam; PF06743; FAST_1; 1.
DR   Pfam; PF08368; FAST_2; 1.
DR   Pfam; PF08373; RAP; 1.
DR   SMART; SM00952; RAP; 1.
DR   PROSITE; PS51286; RAP; 1.
PE   2: Evidence at transcript level;
KW   Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000305"
FT   CHAIN           ?..656
FT                   /note="FAST kinase domain-containing protein 3,
FT                   mitochondrial"
FT                   /id="PRO_0000284717"
FT   DOMAIN          587..645
FT                   /note="RAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00619"
SQ   SEQUENCE   656 AA;  75248 MW;  C058B91DD271D589 CRC64;
     MAFTLRRAFC HMSVFWMPGA VVALKIHPAN NVQKAVRDCL RVWFCSLQPD LFRVRFYHAY
     CKSFHSENGN DLHPVGEPWF SQAQVWNQPE QTLKNEDEEM LSRRLNSFAS FEEVLSFIHT
     LDTLPVTLAS AALLRICEIG KRDDEQRLPK EVLENRVFQA LCLRCERDPS HLTNAVLVTV
     LQSLVIDPQS SLVLSLVAEC QRRLRRGSLE VHHLCVLGES LARLQGASCE ILKLVICQLQ
     SENLETFAPE DIVSVYRILQ ACPEEVDKHQ TFLNTVNNFS LSIVSYLSPK SISHVLTALV
     ALDQTHARPL LIKLGKSVVR YIPRFTNEEL RQVLEAFVYF GHSDRFFTEA LEQHVAAQCF
     SLDPAVASSV MEYCSRKRIL SKPIFDVVAE IFVCQSEKFS PSQISELIEP FGKLNYLPPN
     APALFRKVEN VLFAHLRHFP PKMLLRLLHS CSLIERHPVN FMSKIFSPFF LQRLQGKESY
     LDRLSLAQMT QLFLTSVLEC PFYKGPKLLP KYQVKSFLTP CCSLETPMDL HLYKSVVIGL
     IDLLGSRLYF ASKVLTPYYY TIDVEIKLDE DGFVLPFTVD EDVHTRVALC IDGPQRFCLG
     SKHLLGKEAI KQRHLRLLGY QVVQVPYHEL ELLTSRLELV DYLQRKLFSQ SSTVHW