ID   FAKD4_PIG               Reviewed;         632 AA.
AC   Q7YS91; Q7YS90;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=FAST kinase domain-containing protein 4;
DE   AltName: Full=Cell cycle progression protein 2;
DE   AltName: Full=Protein TBRG4;
DE   AltName: Full=Transforming growth factor beta regulator 4;
DE   Flags: Precursor;
GN   Name=TBRG4; Synonyms=CPR2;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Lung;
RX   PubMed=12759187; DOI=10.1016/s0167-4781(03)00051-4;
RA   Rival-Gervier S., Thepot D., Jolivet G., Houdebine L.-M.;
RT   "Pig whey acidic protein gene is surrounded by two ubiquitously expressed
RT   genes.";
RL   Biochim. Biophys. Acta 1627:7-14(2003).
CC   -!- FUNCTION: Plays a role in processing of mitochondrial RNA precursors
CC       and in stabilization of a subset of mature mitochondrial RNA species,
CC       such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6.
CC       May play a role in cell cycle progression.
CC       {ECO:0000250|UniProtKB:Q969Z0}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000250|UniProtKB:Q969Z0}.
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC       {ECO:0000269|PubMed:12759187}.
CC   -!- SIMILARITY: Belongs to the FAST kinase family. {ECO:0000305}.
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DR   EMBL; AY231143; AAP37946.1; -; Genomic_DNA.
DR   EMBL; AY231134; AAP37946.1; JOINED; Genomic_DNA.
DR   EMBL; AY231135; AAP37946.1; JOINED; Genomic_DNA.
DR   EMBL; AY231136; AAP37946.1; JOINED; Genomic_DNA.
DR   EMBL; AY231137; AAP37946.1; JOINED; Genomic_DNA.
DR   EMBL; AY231138; AAP37946.1; JOINED; Genomic_DNA.
DR   EMBL; AY231139; AAP37946.1; JOINED; Genomic_DNA.
DR   EMBL; AY231140; AAP37946.1; JOINED; Genomic_DNA.
DR   EMBL; AY231141; AAP37946.1; JOINED; Genomic_DNA.
DR   EMBL; AY231142; AAP37946.1; JOINED; Genomic_DNA.
DR   EMBL; AY231144; AAP37947.1; -; mRNA.
DR   AlphaFoldDB; Q7YS91; -.
DR   SMR; Q7YS91; -.
DR   STRING; 9823.ENSSSCP00000017722; -.
DR   PaxDb; Q7YS91; -.
DR   PeptideAtlas; Q7YS91; -.
DR   PRIDE; Q7YS91; -.
DR   eggNOG; ENOG502QTRE; Eukaryota.
DR   InParanoid; Q7YS91; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0090615; P:mitochondrial mRNA processing; ISS:UniProtKB.
DR   GO; GO:0016071; P:mRNA metabolic process; ISS:UniProtKB.
DR   GO; GO:0044528; P:regulation of mitochondrial mRNA stability; ISS:UniProtKB.
DR   InterPro; IPR013579; FAST_2.
DR   InterPro; IPR010622; FAST_Leu-rich.
DR   InterPro; IPR013584; RAP.
DR   Pfam; PF06743; FAST_1; 1.
DR   Pfam; PF08368; FAST_2; 1.
DR   Pfam; PF08373; RAP; 1.
DR   SMART; SM00952; RAP; 1.
DR   PROSITE; PS51286; RAP; 1.
PE   2: Evidence at transcript level;
KW   Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..112
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           113..632
FT                   /note="FAST kinase domain-containing protein 4"
FT                   /id="PRO_0000273028"
FT   DOMAIN          562..620
FT                   /note="RAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00619"
FT   REGION          24..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..52
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        54
FT                   /note="L -> S (in Ref. 1; AAP37947)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        292
FT                   /note="T -> M (in Ref. 1; AAP37946)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        453
FT                   /note="Q -> R (in Ref. 1; AAP37947)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        509
FT                   /note="D -> N (in Ref. 1; AAP37946)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   632 AA;  71220 MW;  6D624A0AB5E9468A CRC64;
     MASRLVRRCT CLLREAARLA PAMSPVGQPR LTRGAPRTLT SSATSPSSHL PGSLSELVER
     GQVFTPYPER QEVDHLIERA TQPEEILALL GGGHCLHQNR AALMVIQLSR LLSEKPKDKA
     LLIKDARFQH LLRLVNSQIN AVWHGTLVKL LRSLYALGLP ATSKELQSVE QEVRWRMRRL
     RYKHLAFLAE SSATYMQEQG SQELLAELLV HLERRWTEID DGRTVVAMMV KIGHLSQSLM
     NRLEDKCLEL VEQFGPEELR KVLVMLAAQN RRSVPLLRAV SYHLVQKPFT LTKSILLDLA
     YAYGKLGFHQ TQVFQRLAAD LLPHTPSLTS SEVARCTKSF AFLKWLSLPL FEAFAQHVLD
     RAQSIALPHL CNMLLAFARV NFRPEREDQF FSLVHEKLGS QLAGLEPALQ VDVVWSLCVL
     QQAREAELQA VLRPELHGQF LGDKSPKDQS TFQKLLHINA TAQLEHPEYT GPHLPSSALV
     PRPSALDKKV TPLQKELQET LKGLLGSADK GSFLVATRYG WILDAEVLLD ADSQLLPLRD
     FVAPHLAQPS GSQPLPAGAK RLAFLCWEFP NFNSRSKDLL GRFVLARRHL LAAGFLLVDV
     PYYEWLELKS EWQKSAYLKD KMRKAAAEEL AK