ID   FAKD4_RAT               Reviewed;         629 AA.
AC   Q5M9G9;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=FAST kinase domain-containing protein 4;
DE   AltName: Full=Protein TBRG4;
DE   AltName: Full=Transforming growth factor beta regulator 4;
DE   Flags: Precursor;
GN   Name=Tbrg4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays a role in processing of mitochondrial RNA precursors
CC       and in stabilization of a subset of mature mitochondrial RNA species,
CC       such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6.
CC       May play a role in cell cycle progression.
CC       {ECO:0000250|UniProtKB:Q969Z0}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000250|UniProtKB:Q969Z0}.
CC   -!- SIMILARITY: Belongs to the FAST kinase family. {ECO:0000305}.
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DR   EMBL; BC087073; AAH87073.1; -; mRNA.
DR   RefSeq; NP_001012154.1; NM_001012154.1.
DR   RefSeq; XP_006251404.1; XM_006251342.3.
DR   RefSeq; XP_006251405.1; XM_006251343.3.
DR   AlphaFoldDB; Q5M9G9; -.
DR   SMR; Q5M9G9; -.
DR   IntAct; Q5M9G9; 2.
DR   STRING; 10116.ENSRNOP00000053972; -.
DR   iPTMnet; Q5M9G9; -.
DR   PhosphoSitePlus; Q5M9G9; -.
DR   jPOST; Q5M9G9; -.
DR   PaxDb; Q5M9G9; -.
DR   PRIDE; Q5M9G9; -.
DR   Ensembl; ENSRNOT00000089133; ENSRNOP00000074223; ENSRNOG00000052477.
DR   GeneID; 360977; -.
DR   KEGG; rno:360977; -.
DR   UCSC; RGD:1309737; rat.
DR   CTD; 9238; -.
DR   RGD; 1309737; Tbrg4.
DR   eggNOG; ENOG502QTRE; Eukaryota.
DR   GeneTree; ENSGT01030000234607; -.
DR   HOGENOM; CLU_029448_0_0_1; -.
DR   InParanoid; Q5M9G9; -.
DR   OMA; EPVFTPY; -.
DR   OrthoDB; 1209476at2759; -.
DR   PhylomeDB; Q5M9G9; -.
DR   TreeFam; TF324885; -.
DR   PRO; PR:Q5M9G9; -.
DR   Proteomes; UP000002494; Chromosome 14.
DR   Bgee; ENSRNOG00000052477; Expressed in duodenum and 19 other tissues.
DR   Genevisible; Q5M9G9; RN.
DR   GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0035770; C:ribonucleoprotein granule; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0090615; P:mitochondrial mRNA processing; ISS:UniProtKB.
DR   GO; GO:0000963; P:mitochondrial RNA processing; IBA:GO_Central.
DR   GO; GO:0016071; P:mRNA metabolic process; ISS:UniProtKB.
DR   GO; GO:0044528; P:regulation of mitochondrial mRNA stability; ISS:UniProtKB.
DR   InterPro; IPR013579; FAST_2.
DR   InterPro; IPR010622; FAST_Leu-rich.
DR   InterPro; IPR013584; RAP.
DR   Pfam; PF06743; FAST_1; 1.
DR   Pfam; PF08368; FAST_2; 1.
DR   Pfam; PF08373; RAP; 1.
DR   SMART; SM00952; RAP; 1.
DR   PROSITE; PS51286; RAP; 1.
PE   2: Evidence at transcript level;
KW   Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000305"
FT   CHAIN           ?..629
FT                   /note="FAST kinase domain-containing protein 4"
FT                   /id="PRO_0000273029"
FT   DOMAIN          559..617
FT                   /note="RAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00619"
SQ   SEQUENCE   629 AA;  71181 MW;  BE6CA495C747BC6E CRC64;
     MAVRLMKQCT CLLREATRLV PTVAPVGRLR LAGVACKTLT SSVSSPSSGS LTELLGKEQV
     FTPYPEHQEV DYLIEKATRP EELLELLGGD HSLHHNHAAL ILIRLSYLLS EKPKEKALLV
     EDARFQQLVR LVDSQITSVW HGTLVKLLRS LYTLVLPQGS KELRSVEQEV RWRLRRLKYK
     HLVFLAESCA PFMKEQHSKE LLAELLRHLE RRWTEISDSR TLVSMMTMAG HLSESLMNRL
     EDKCLELVEQ FGPDELRKVL MTLAAQSRRS VPLLRAISYH LVQKPFPMTK GMLLDLAYAY
     GKLSFHQTQV AQRLAADLLP FIPSMTPGEV ARCAKSFAFL KWLNLPLFEA FTQHLLNSAQ
     DVSLSHLCSV LLAFARLNFH PEQEDQFFNL VHEKLDSVLG SLEPALQVDL VWALCVLQQV
     QVAELQTVLH PGLHTRFLES KSPKDQSTFQ KLVHINSTAL LEYPEYKGPF LPASAVAPSP
     SPSNKKMTPL QKELQDALKA LLGNNDTGSL EVATQYGWVL DAEVLLDAEG HFLPLRDFVA
     PHLAQPVGNQ PLPPGAKRIA FLRWEFPNFN SRSKDLLGRF VLARRHVLAA GFLVVDVPYY
     EWLDLKSEWQ KTAYLKDKMR KAVAEELAK