ID   FAKD4_XENLA             Reviewed;         633 AA.
AC   Q6PA48;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=FAST kinase domain-containing protein 4;
DE   AltName: Full=Protein TBRG4;
DE   AltName: Full=Transforming growth factor beta regulator 4;
DE   Flags: Precursor;
GN   Name=tbrg4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in processing of mitochondrial RNA precursors
CC       and in stabilization of a subset of mature mitochondrial RNA species.
CC       May play a role in cell cycle progression.
CC       {ECO:0000250|UniProtKB:Q969Z0}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000250|UniProtKB:Q969Z0}.
CC   -!- SIMILARITY: Belongs to the FAST kinase family. {ECO:0000305}.
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DR   EMBL; BC060456; AAH60456.1; -; mRNA.
DR   RefSeq; NP_001083350.1; NM_001089881.1.
DR   AlphaFoldDB; Q6PA48; -.
DR   SMR; Q6PA48; -.
DR   DNASU; 398879; -.
DR   GeneID; 398879; -.
DR   KEGG; xla:398879; -.
DR   CTD; 398879; -.
DR   Xenbase; XB-GENE-969732; tbrg4.L.
DR   OrthoDB; 1209476at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 398879; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0090615; P:mitochondrial mRNA processing; ISS:UniProtKB.
DR   GO; GO:0016071; P:mRNA metabolic process; ISS:UniProtKB.
DR   GO; GO:0044528; P:regulation of mitochondrial mRNA stability; ISS:UniProtKB.
DR   InterPro; IPR013579; FAST_2.
DR   InterPro; IPR010622; FAST_Leu-rich.
DR   InterPro; IPR013584; RAP.
DR   Pfam; PF06743; FAST_1; 1.
DR   Pfam; PF08368; FAST_2; 1.
DR   Pfam; PF08373; RAP; 1.
DR   SMART; SM00952; RAP; 1.
DR   PROSITE; PS51286; RAP; 1.
PE   2: Evidence at transcript level;
KW   Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000305"
FT   CHAIN           ?..633
FT                   /note="FAST kinase domain-containing protein 4"
FT                   /id="PRO_0000273030"
FT   DOMAIN          563..621
FT                   /note="RAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00619"
SQ   SEQUENCE   633 AA;  71853 MW;  8709BA055037A2E4 CRC64;
     MAARLVQRCS RLLAASTAYA PATPAHIQEC IKGFHPAQPL ISCSFLHSSS LCRHIDKVVA
     KEQPVGSVPE HGKFESLLES LSSVEELLQL AADREISSNQ AAMIVTQVSK ILIESKAQPD
     STVQDQRFQQ LLLQTHNQLS TIWNGNLVSL LKRLYMLGIK EDNRQLQALE NEVRWRMRRL
     SFKSLVQLSD MYMTFDRTPE QKQLVSDLVK NLELRWTEIE DAKSVVTLMT RVGFISKSLM
     EKLEDKALEY AEHFTPDETR KVALALAAQN RRSVALLRAL SYHLVQRHFA LSPPVVVDLA
     YAYGKLNFHQ TQVFQKMASD LLPNVPEMSP SDISRCIKSF AYLKWSNLPL FEAFAQTSID
     RCEKFTVLQL CNLVLAFGRL NFQPSKQEEF YNMVHQRLHT ELDLLNPYLL VDVVWSLCVL
     QQVNSSYISK VLEPDFCSKF FTDGSPRSAN YRLKLAHINA AALLEHPDYT GSLLPVESIS
     AAQSVSANRK LSPLQSGLQE VLREVFPVEG TCRYGVDTVY GWYIDGEVVV DSDNKALPLT
     DLQTPNLLQS QGKKPLPGGA RRFAFVGWDF PNFNSRSKDL LGRFVMTRRH LQAAGYLLVE
     VPYYEWLDLK SEWQKSAYVK DKINKAVAEE MAR