ID   FAKD4_XENTR             Reviewed;         633 AA.
AC   Q6DJ55;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=FAST kinase domain-containing protein 4;
DE   AltName: Full=Protein TBRG4;
DE   AltName: Full=Transforming growth factor beta regulator 4;
DE   Flags: Precursor;
GN   Name=tbrg4;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in processing of mitochondrial RNA precursors
CC       and in stabilization of a subset of mature mitochondrial RNA species.
CC       May play a role in cell cycle progression.
CC       {ECO:0000250|UniProtKB:Q969Z0}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000250|UniProtKB:Q969Z0}.
CC   -!- SIMILARITY: Belongs to the FAST kinase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH75328.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC075328; AAH75328.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001004904.2; NM_001004904.1.
DR   AlphaFoldDB; Q6DJ55; -.
DR   STRING; 8364.ENSXETP00000028145; -.
DR   PaxDb; Q6DJ55; -.
DR   DNASU; 448262; -.
DR   GeneID; 448262; -.
DR   KEGG; xtr:448262; -.
DR   CTD; 9238; -.
DR   Xenbase; XB-GENE-969727; tbrg4.
DR   eggNOG; ENOG502QTRE; Eukaryota.
DR   InParanoid; Q6DJ55; -.
DR   OrthoDB; 1209476at2759; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000023866; Expressed in gastrula and 14 other tissues.
DR   GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0035770; C:ribonucleoprotein granule; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0090615; P:mitochondrial mRNA processing; ISS:UniProtKB.
DR   GO; GO:0000963; P:mitochondrial RNA processing; IBA:GO_Central.
DR   GO; GO:0016071; P:mRNA metabolic process; ISS:UniProtKB.
DR   GO; GO:0044528; P:regulation of mitochondrial mRNA stability; ISS:UniProtKB.
DR   InterPro; IPR013579; FAST_2.
DR   InterPro; IPR010622; FAST_Leu-rich.
DR   InterPro; IPR013584; RAP.
DR   Pfam; PF06743; FAST_1; 1.
DR   Pfam; PF08368; FAST_2; 1.
DR   Pfam; PF08373; RAP; 1.
DR   SMART; SM00952; RAP; 1.
DR   PROSITE; PS51286; RAP; 1.
PE   2: Evidence at transcript level;
KW   Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000305"
FT   CHAIN           ?..633
FT                   /note="FAST kinase domain-containing protein 4"
FT                   /id="PRO_0000273031"
FT   DOMAIN          563..621
FT                   /note="RAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00619"
SQ   SEQUENCE   633 AA;  71840 MW;  F4DD53EBEDDB04FF CRC64;
     MAARLVQRCS RLLAASTAYA PATHTHIHEC MKVCHPAQPV LPCSSLHSSS LCRHKDKALT
     KEQTVSSVPE HGKFESVLES LSSVEELLQL GVDREISGNQ AAMIITQVSK VLMESKAQGG
     SVVQDERFQQ LLVQAHNQIS TIWNGNLVSL LKRLYILGIR EDNKQLQAVE NEVRWRLRRL
     SFKSLVQLSD LYVTFTRSPE QKHLVSDLVK NLELRWTEIE DAKSVVTLMT RVGFISKALM
     EKLEDKALEY AEQFTPDEMR KVALALAAQN RRTVPLLRAL SYHLVQRHIG LSPAVVVDLA
     FAYGKLNFHQ TQVFQKMASD LLPKVPEMSA NDIARCVKSF AYLKWSNLPL FEAFAQASID
     QSEKFTVPQL CNLVLAFGRL NFQPSKREEF YSMMHQKLHA ELDLLDPYLL VDIVWSLCVL
     RQVDSSYISK VLEPGLYSRF FTDSSPRSAN YRLKLAHINA TALLEHPEYT GPHLPNESIS
     TTHAVTANRK LSPLQSGLQE VLRELFPVEG TCRCGVNTVY GWYIDGEVVL DSDNKPLSLM
     DLEAPHLPHS QGKKPLPEGT RRFAFVAWDF PNFNSRSKDL LGRFVLTRRH LQAAGFLVVE
     VPYYEWLDLK SEWQKSAYLK DKINKVVAEE MAR