ID   FAKD5_MACFA             Reviewed;         764 AA.
AC   Q95KD0; Q9BGU7;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=FAST kinase domain-containing protein 5, mitochondrial;
DE   Flags: Precursor;
GN   Name=FASTKD5; ORFNames=QflA-14044, QmoA-10101;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Frontal cortex, and Medulla oblongata;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the processing of non-canonical
CC       mitochondrial mRNA precursors. {ECO:0000250|UniProtKB:Q7L8L6}.
CC   -!- SUBUNIT: Found in a complex with GRSF1, DDX28, DHX30 and FASTKD2.
CC       Associates with the 12S mitochondrial rRNA (12S mt-rRNA).
CC       {ECO:0000250|UniProtKB:Q7L8L6}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid
CC       {ECO:0000250|UniProtKB:Q7L8L6}. Note=Localizes to mitochondrial RNA
CC       granules found in close proximity to the mitochondrial nucleoids.
CC       {ECO:0000250|UniProtKB:Q7L8L6}.
CC   -!- SIMILARITY: Belongs to the FAST kinase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB21934.1; Type=Frameshift; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB062957; BAB60739.1; -; mRNA.
DR   EMBL; AB055309; BAB21934.1; ALT_FRAME; mRNA.
DR   AlphaFoldDB; Q95KD0; -.
DR   SMR; Q95KD0; -.
DR   STRING; 9541.XP_005568543.1; -.
DR   eggNOG; ENOG502QRPY; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0042645; C:mitochondrial nucleoid; ISS:UniProtKB.
DR   GO; GO:0035770; C:ribonucleoprotein granule; ISS:UniProtKB.
DR   GO; GO:0019843; F:rRNA binding; ISS:UniProtKB.
DR   GO; GO:0000963; P:mitochondrial RNA processing; ISS:UniProtKB.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0044528; P:regulation of mitochondrial mRNA stability; IEA:InterPro.
DR   InterPro; IPR013579; FAST_2.
DR   InterPro; IPR010622; FAST_Leu-rich.
DR   InterPro; IPR013584; RAP.
DR   Pfam; PF06743; FAST_1; 1.
DR   Pfam; PF08368; FAST_2; 1.
DR   Pfam; PF08373; RAP; 1.
DR   SMART; SM00952; RAP; 1.
DR   PROSITE; PS51286; RAP; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Mitochondrion; Mitochondrion nucleoid; mRNA processing;
KW   Phosphoprotein; Reference proteome; RNA-binding; rRNA-binding;
KW   Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000305"
FT   CHAIN           ?..764
FT                   /note="FAST kinase domain-containing protein 5,
FT                   mitochondrial"
FT                   /id="PRO_0000284980"
FT   DOMAIN          697..757
FT                   /note="RAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00619"
FT   MOD_RES         95
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7L8L6"
FT   MOD_RES         507
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7L8L6"
FT   CONFLICT        745
FT                   /note="K -> E (in Ref. 1; BAB21934)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   764 AA;  86621 MW;  EB04FA4554DA3EEC CRC64;
     MAATLKSLKL LRYRALCSPS ACGAARSVSY WNVSSKQHGG QDPPEHISLC HSAKRVKNIC
     STFSSRRILT TSSACPGLEF SKTSSSKAST LQLDSPRATR VDEEDVEVFD SFANIRVFLQ
     LRPEYRVHSY NASETSQLLS VSESELILHK VTVYQNKLQA QVIVDYLCKL SSLPAEQHPV
     LLRSTSFALL CQLSVKKIQL FDTQDLINVL KAFVILGIPH SHSMLDVYET KCCHQVWEMS
     MDQLLLVADL WRYLGRKIPR FLNIFSSYLN LHWKDLSLSQ LVHLIYVIGE NRQVSQDLMQ
     KLESLILKYI DLINLEEVGT ICLGFFKSKT SLSEFVMRKI GDLACANMQH LSSHALVNIV
     KMFRFTHVDH INFMKQLGEI APQRIPSLGV QGVMHLTLYC SALRFLDEGV MNAVAASLPC
     RVAHCRSKDV AKILWSFGTL NYKPPNAEEF YSSLINEIHR KMPEFNQYPE HLPTCLLGLA
     FSEYFPVELI DFALSPGFVR LAQERTKFNL IKELYTLDGT VGIECPDYRG NRLSTHLQQE
     GSEFLWNLAE KDMNSKPEFL ETLFLLETML GGPQYVKHHM ILPHTRSSDL EVQLDVNLKP
     LPFNREATPA ENVATLRLKH VGVSLTDDLM NQLLKGKARG HFQGKTESEP GQQPMELENK
     AAVPLGGFLC NVADKSGAME MAGLCPSACM QTPGMKLAIQ FTNRNQYCYG SRDLLGLHSM
     KRRQLARLGY RVVELSYWEW FPLLKRTRLE KLAFLHEKVF TSAL