FAKD5_MOUSE
ID FAKD5_MOUSE Reviewed; 762 AA.
AC Q7TMV3; Q3UNY5; Q5DTV0;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=FAST kinase domain-containing protein 5, mitochondrial;
DE Flags: Precursor;
GN Name=Fastkd5; Synonyms=Kiaa1792;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C3H/He; TISSUE=Mesenchymal stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=20869947; DOI=10.1016/j.bbrc.2010.09.075;
RA Simarro M., Gimenez-Cassina A., Kedersha N., Lazaro J.B., Adelmant G.O.,
RA Marto J.A., Rhee K., Tisdale S., Danial N., Benarafa C., Orduna A.,
RA Anderson P.;
RT "Fast kinase domain-containing protein 3 is a mitochondrial protein
RT essential for cellular respiration.";
RL Biochem. Biophys. Res. Commun. 401:440-446(2010).
CC -!- FUNCTION: Plays an important role in the processing of non-canonical
CC mitochondrial mRNA precursors. {ECO:0000250|UniProtKB:Q7L8L6}.
CC -!- SUBUNIT: Found in a complex with GRSF1, DDX28, DHX30 and FASTKD2.
CC Associates with the 12S mitochondrial rRNA (12S mt-rRNA).
CC {ECO:0000250|UniProtKB:Q7L8L6}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid
CC {ECO:0000250|UniProtKB:Q7L8L6}. Note=Localizes to mitochondrial RNA
CC granules found in close proximity to the mitochondrial nucleoids.
CC {ECO:0000250|UniProtKB:Q7L8L6}.
CC -!- TISSUE SPECIFICITY: Expression detected in spleen, testis, colon,
CC heart, smooth muscle, kidney, brain, lung, liver, brown and white
CC adipose tissue. {ECO:0000269|PubMed:20869947}.
CC -!- SIMILARITY: Belongs to the FAST kinase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD90466.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE25612.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK143929; BAE25612.1; ALT_INIT; mRNA.
DR EMBL; AK220420; BAD90466.1; ALT_INIT; mRNA.
DR EMBL; AL731707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC052898; AAH52898.1; -; mRNA.
DR CCDS; CCDS50713.2; -.
DR RefSeq; NP_001139556.1; NM_001146084.1.
DR RefSeq; NP_937819.2; NM_198176.2.
DR AlphaFoldDB; Q7TMV3; -.
DR BioGRID; 237566; 12.
DR IntAct; Q7TMV3; 1.
DR MINT; Q7TMV3; -.
DR STRING; 10090.ENSMUSP00000105891; -.
DR PhosphoSitePlus; Q7TMV3; -.
DR EPD; Q7TMV3; -.
DR MaxQB; Q7TMV3; -.
DR PaxDb; Q7TMV3; -.
DR PeptideAtlas; Q7TMV3; -.
DR PRIDE; Q7TMV3; -.
DR ProteomicsDB; 275584; -.
DR Antibodypedia; 23456; 99 antibodies from 19 providers.
DR DNASU; 380601; -.
DR Ensembl; ENSMUST00000110262; ENSMUSP00000105891; ENSMUSG00000079043.
DR GeneID; 380601; -.
DR KEGG; mmu:380601; -.
DR UCSC; uc008mjm.3; mouse.
DR CTD; 60493; -.
DR MGI; MGI:2139469; Fastkd5.
DR VEuPathDB; HostDB:ENSMUSG00000079043; -.
DR eggNOG; ENOG502QRPY; Eukaryota.
DR GeneTree; ENSGT01030000234607; -.
DR InParanoid; Q7TMV3; -.
DR OMA; KRMILPH; -.
DR OrthoDB; 452836at2759; -.
DR PhylomeDB; Q7TMV3; -.
DR TreeFam; TF352874; -.
DR BioGRID-ORCS; 380601; 16 hits in 71 CRISPR screens.
DR PRO; PR:Q7TMV3; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q7TMV3; protein.
DR Bgee; ENSMUSG00000079043; Expressed in otic placode and 275 other tissues.
DR ExpressionAtlas; Q7TMV3; baseline and differential.
DR GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0042645; C:mitochondrial nucleoid; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0035770; C:ribonucleoprotein granule; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; ISS:UniProtKB.
DR GO; GO:0000963; P:mitochondrial RNA processing; ISS:UniProtKB.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0044528; P:regulation of mitochondrial mRNA stability; IBA:GO_Central.
DR InterPro; IPR013579; FAST_2.
DR InterPro; IPR010622; FAST_Leu-rich.
DR InterPro; IPR013584; RAP.
DR Pfam; PF06743; FAST_1; 1.
DR Pfam; PF08368; FAST_2; 1.
DR Pfam; PF08373; RAP; 1.
DR SMART; SM00952; RAP; 1.
DR PROSITE; PS51286; RAP; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Mitochondrion; Mitochondrion nucleoid; mRNA processing;
KW Phosphoprotein; Reference proteome; RNA-binding; rRNA-binding;
KW Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000305"
FT CHAIN ?..762
FT /note="FAST kinase domain-containing protein 5,
FT mitochondrial"
FT /id="PRO_0000284981"
FT DOMAIN 695..755
FT /note="RAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00619"
FT MOD_RES 95
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7L8L6"
FT MOD_RES 506
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q7L8L6"
SQ SEQUENCE 762 AA; 86600 MW; EA0224EAE072CDAC CRC64;
MSAALKLLEP LKYKAPCNPA YRAAQSVAHW HMGNITPHGG QTLPECNSSC HLARKVKNVG
GTTLPRRTFT ASSAHLGLEF NKASTLNAST LHPDSSSAGG GEEDVEVFDS FEGTRVFLKL
RPEYQLHSYN RSDTHQPIAA SEVELILHKV TFYQNKLQPE VITNYFYKLS SLPAEQNSVL
LSSNSFALLC QLSVKNIQLF NTSDLISILK AFVDLRIPPS LSMLDVYETR FCHQVWEMTL
DQLLLVADLW RNLGRRVPRF FKIFFSYLNL HWRELSLSQL IHLIYIIGEN RQVPQDLMQR
LESLILKYVD SVNLEEVGTI CLGFFKSSSS LSEFVMRKIG DLACANMQHL SSHTLVHILK
MFRFTHVDHI HFMKQFGEIA PQRIPSLGVQ GVMHLTLACS ALRILDERVM NAVAASLPPR
VAHCRSKDVA KILWSFGTLN YKPPNTEEFY SSLINEIHRK MPEFNQYPEH LLTCLIGLAF
SEYFPVEFIN VALSPGFVKL AQERSKFELT KELFTLDGTV AIECPDYKGN RLNSHLQQET
SANLWNLASK DMRSKPEFLE TLYLLETMLG GPQYIKHHMI LPHTRSSDLE VQLDANMKPM
PFNSEATPTE DGAQLRFKQV GVSLTDDLMN QLLKGKAKRY FQGQIELETG QPPMELRKKT
TVPLVNSGCN GTDRLGDGMV GLCPLAHMQP PLVKLAIQFT NKNQYCYGSR ALLGLHNMKR
RQLVQIGYRV VELPHWEWLP LLKRTRLEKL AYLHEKVFTS AL
