ID   FAKD5_PONAB             Reviewed;         764 AA.
AC   Q5RFI6; Q5R624;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=FAST kinase domain-containing protein 5, mitochondrial;
DE   Flags: Precursor;
GN   Name=FASTKD5;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex, and Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the processing of non-canonical
CC       mitochondrial mRNA precursors. {ECO:0000250|UniProtKB:Q7L8L6}.
CC   -!- SUBUNIT: Found in a complex with GRSF1, DDX28, DHX30 and FASTKD2.
CC       Associates with the 12S mitochondrial rRNA (12S mt-rRNA).
CC       {ECO:0000250|UniProtKB:Q7L8L6}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid
CC       {ECO:0000250|UniProtKB:Q7L8L6}. Note=Localizes to mitochondrial RNA
CC       granules found in close proximity to the mitochondrial nucleoids.
CC       {ECO:0000250|UniProtKB:Q7L8L6}.
CC   -!- SIMILARITY: Belongs to the FAST kinase family. {ECO:0000305}.
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DR   EMBL; CR857170; CAH89471.1; -; mRNA.
DR   EMBL; CR860676; CAH92792.1; -; mRNA.
DR   RefSeq; NP_001124632.1; NM_001131160.1.
DR   AlphaFoldDB; Q5RFI6; -.
DR   GeneID; 100171471; -.
DR   KEGG; pon:100171471; -.
DR   CTD; 60493; -.
DR   InParanoid; Q5RFI6; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0042645; C:mitochondrial nucleoid; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0035770; C:ribonucleoprotein granule; ISS:UniProtKB.
DR   GO; GO:0019843; F:rRNA binding; ISS:UniProtKB.
DR   GO; GO:0000963; P:mitochondrial RNA processing; ISS:UniProtKB.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0044528; P:regulation of mitochondrial mRNA stability; IEA:InterPro.
DR   InterPro; IPR013579; FAST_2.
DR   InterPro; IPR010622; FAST_Leu-rich.
DR   InterPro; IPR013584; RAP.
DR   Pfam; PF06743; FAST_1; 1.
DR   Pfam; PF08368; FAST_2; 1.
DR   Pfam; PF08373; RAP; 1.
DR   SMART; SM00952; RAP; 1.
DR   PROSITE; PS51286; RAP; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Mitochondrion; Mitochondrion nucleoid; mRNA processing;
KW   Phosphoprotein; Reference proteome; RNA-binding; rRNA-binding;
KW   Transit peptide.
FT   TRANSIT         1..27
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..764
FT                   /note="FAST kinase domain-containing protein 5,
FT                   mitochondrial"
FT                   /id="PRO_0000284982"
FT   DOMAIN          697..757
FT                   /note="RAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00619"
FT   REGION          68..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         95
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7L8L6"
FT   MOD_RES         507
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7L8L6"
FT   CONFLICT        186
FT                   /note="S -> G (in Ref. 1; CAH92792)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        592
FT                   /note="V -> A (in Ref. 1; CAH92792)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   764 AA;  86556 MW;  BEE5D00C7E19CD39 CRC64;
     MAATLKSLKL LRYQAFCSPS AFGAVRSVSY WNASSTQHGG QDPPGHISLC HSAKKVKNIC
     STFSSRRIPT TSSARPGLEF SKTSSSKAST LQLGSPRATG IDEENVEVFD SFENLRVFLQ
     LRPEYRVHSY SASETSQLLS VSEGELILHK VRVNQNNLQA QVIVDYLCKL SSLPAEQHPV
     LLGSTSFALL CQLSVRKIKL FDTQDLINVL KAFVILGIPH SHSMLDVYET KCCHQVWEMS
     VDQLLLVADL WRYIGRKVPR FLNICCSYLN LRWKDLSLSQ LVHLIYVIGE NRQVSQDLMQ
     KLESLILKYI DLINLEEVGT ICLGFFKSKT NLSEFVMRKI GDLACADMQH LSSHSLVNIV
     KMFRFTHVDH INFMKQIGEI APQRIPSLGV QGVMHLTLYC SALRFLDEGV MNAVAASLPP
     RVAQCRSKDV AKILWSFGTL NYKPPNAEEF YSSLINEIHR KMPEFNQYPE HLPTCLLGLA
     FLEYFPVELI DFALSPGFVR LAQERTKFDL IKELYTLDGT VVIECPDYRG NRLSTHLQRE
     GSELLWYLAE KDMNSKPEFL ETVFLLETML GGPQYVKHHM ILPHTRSSDL EVQLDVNLKP
     LPFNREATPA ENVAKLKCEH VGVSLTDDLM NQLLKGKARG HFQGKTESEP GQQHMELENK
     AAVPLGGSLR NVADKSGAME MAGLCPPACM QTPRMKLAIQ FTNRNQYCYG SRDLLGLHNM
     KRRQLARLGY RVVELSYWEW LPLLKRTRLE KLAFLHEKVF TSAL